EFFECT OF BIARUM CARDUCHRUM IN 6-HYDROXYDOPAMINE-INDUCED PARKINSONISM IN RATS: USING BEHAVIORAL TESTS

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SETORKI MAHBUBEH; MAHMOUDI RAZIEH; ZANGANEHNEJAD ZAHRA

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:2 Page(s): 113-120

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Title

EFFECT OF BIARUM CARDUCHRUM IN 6-HYDROXYDOPAMINE-INDUCED PARKINSONISM IN RATS: USING BEHAVIORAL TESTS

Author(s)

SETORKI MAHBUBEH | MAHMOUDI RAZIEH | ZANGANEHNEJAD ZAHRA | Issue Writer Certificate

Keywords

BIARUM CARDUCHRUMQ1

DOPAMINEQ2

PARKINSONQ2

Abstract

Introduction PARKINSON's disease results from degenerative loss of DOPAMINErgic neurons in the substantia nigra and other part of the brain stem. The aim of this study is to evaluate the effect of BIARUM CARDUCHRUM extract in treatment of PARKINSON's disease.Methods: Rats were divided randomly into five groups of eight animals. The control group did not receive any lesion. In PARKINSON's group, PARKINSON was induced by injection of 6- OHDA in the right anterior mid-brain (MFB). Third, fourth and fifth groups received BIARUM CARDUCHRUM extract at doses of 100, 200 and 400 mg/kg via gavage for 14 days, 7 days after induction of PARKINSON models. On day 15 behavioral tests, including catalepsy and open field, was performed.Results: PARKINSONian group showed higher immobility time than control group in catalepsy test and rats treatment with BIARUM CARDUCHRUM extract at doses of 200 and 400 dramatically reduced the immobilization time.Discussion: The results of this study show that BIARUM CARDUCHRUM extract can improve motor impairment induced by PARKINSON' s.

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APA: Copy

SETORKI, MAHBUBEH, MAHMOUDI, RAZIEH, & ZANGANEHNEJAD, ZAHRA. (2018). EFFECT OF BIARUM CARDUCHRUM IN 6-HYDROXYDOPAMINE-INDUCED PARKINSONISM IN RATS: USING BEHAVIORAL TESTS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(2 ), 113-120. SID. https://sid.ir/paper/81786/en

Vancouver: Copy

SETORKI MAHBUBEH, MAHMOUDI RAZIEH, ZANGANEHNEJAD ZAHRA. EFFECT OF BIARUM CARDUCHRUM IN 6-HYDROXYDOPAMINE-INDUCED PARKINSONISM IN RATS: USING BEHAVIORAL TESTS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(2 ):113-120. Available from: https://sid.ir/paper/81786/en

IEEE: Copy

MAHBUBEH SETORKI, RAZIEH MAHMOUDI, and ZAHRA ZANGANEHNEJAD, “EFFECT OF BIARUM CARDUCHRUM IN 6-HYDROXYDOPAMINE-INDUCED PARKINSONISM IN RATS: USING BEHAVIORAL TESTS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 2 , pp. 113–120, 2018, [Online]. Available: https://sid.ir/paper/81786/en

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