ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF BLACK PEPPER (PIPER NIGRUM) AND MARCH (PEGANUM HARMALA) AGAINST ANTIBIOTIC-RESISTANT OF STAPHYLOCOCCUS AUREUS STRAINS

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SABBAGH SEYED KAZEM; SAEEDI SAEEDACH; DEHBASHI ZAHRA; MAZAHERI NAEEINI MAHTA

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Journal: Journal of Sabzevar University of Medical Sciences Year:2015 | Volume:22 | Issue:5 Page(s): 854-861

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Title

ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF BLACK PEPPER (PIPER NIGRUM) AND MARCH (PEGANUM HARMALA) AGAINST ANTIBIOTIC-RESISTANT OF STAPHYLOCOCCUS AUREUS STRAINS

Author(s)

SABBAGH SEYED KAZEM | SAEEDI SAEEDACH | DEHBASHI ZAHRA | MAZAHERI NAEEINI MAHTA | Issue Writer Certificate

Keywords

CHEMICAL DRUGSQ1

ANTIBACTERIAL EFFECTQ3

PLANT EXTRACTQ2

PIPER NIGRUMQ3

PEGANUM HARMALAQ2

Abstract

Background and aim: Staphylococcus aureus is on of the most infectious agents to humans. In recent years, resistance strain to different antibiotic has been reported. With increasing of bacterial resistance to CHEMICAL DRUGS and effects of plant medicines, herbal medicines have been considered as alternative medicaments. The purpose of this study was to investigate the antimicrobial activity of alcoholic extract of Black pepper and March against clinical isolates of Staphylococcus aureus resistant to commonly used antibiotics.Materials and Methods: Alcholic PLANT EXTRACTion was done using a rotary apparatus. Twelve, Staphylococcus aureus strains from urine samples was isolated and then purified. The minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBI) of the PLANT EXTRACTs at six different concentrations was determined broth medium using dilution method. Susceptibility of strains to multiple antibiotics was evaluated using Kirby-Bauer disk diffusion method.Result: The results of this study showed that higher and lower average resistance to tested antibiotic is belonged to Ceftazidime (66.66%) and vancomycin (8.1%) antibiotic, respectively. MIC assay of PLANT EXTRACTs showed that the highest effect of Pepper and March was determined at concentrations of 10 and 5 mg/ml, respectively. Whereas, the lowest MIC effect for Pepper and March was recorded at concentration of 2.5 and 0.62 mg/mL, respectively. The maximum MBC of PLANT EXTRACTs was recorded at concentration of 20 and 10 mg/mL for Pepper and March, respectively.Conclusion: Although the clinical application of PLANT EXTRACTs and essential oils due to fewer side effects, seems valuable, However, to clinical application of the alcoholic extract of black pepper and march more researches on mode of action of effective compounds of plans on microbial agents have to be done.

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APA: Copy

SABBAGH, SEYED KAZEM, SAEEDI, SAEEDACH, DEHBASHI, ZAHRA, & MAZAHERI NAEEINI, MAHTA. (2015). ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF BLACK PEPPER (PIPER NIGRUM) AND MARCH (PEGANUM HARMALA) AGAINST ANTIBIOTIC-RESISTANT OF STAPHYLOCOCCUS AUREUS STRAINS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 22(5), 854-861. SID. https://sid.ir/paper/81858/en

Vancouver: Copy

SABBAGH SEYED KAZEM, SAEEDI SAEEDACH, DEHBASHI ZAHRA, MAZAHERI NAEEINI MAHTA. ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF BLACK PEPPER (PIPER NIGRUM) AND MARCH (PEGANUM HARMALA) AGAINST ANTIBIOTIC-RESISTANT OF STAPHYLOCOCCUS AUREUS STRAINS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(5):854-861. Available from: https://sid.ir/paper/81858/en

IEEE: Copy

SEYED KAZEM SABBAGH, SAEEDACH SAEEDI, ZAHRA DEHBASHI, and MAHTA MAZAHERI NAEEINI, “ANTIMICROBIAL ACTIVITY OF ETHANOLIC EXTRACT OF BLACK PEPPER (PIPER NIGRUM) AND MARCH (PEGANUM HARMALA) AGAINST ANTIBIOTIC-RESISTANT OF STAPHYLOCOCCUS AUREUS STRAINS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 854–861, 2015, [Online]. Available: https://sid.ir/paper/81858/en

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