CYTOTOXICITY EFFECT OF SYNTHETIC CHALCONE DERIVED FROM 4-METHOXYPHENYL ON HELA CELL LINE

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SEYEDALIPOUR BAGHER; FAZELI MOGHADASE; AHMADY ASBCHIN SALMAN; CHESHOMI HAMID; ALDAGHI LEILASADAT

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Journal: Journal of Sabzevar University of Medical Sciences Year:2015 | Volume:22 | Issue:5 Page(s): 919-926

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Title

CYTOTOXICITY EFFECT OF SYNTHETIC CHALCONE DERIVED FROM 4-METHOXYPHENYL ON HELA CELL LINE

Author(s)

Keywords

CHALCONEQ1

HELAQ1

CYTOTOXICITYQ2

MTTQ2

Abstract

Background and objective: CHALCONEs are belonged to an important group of flavonoids which has proven anti-inflammatory and antineoplastic effects. Assessing cellular CYTOTOXICITY effect of new synthetic CHALCONE on HELA cell line is the aim of present study.Materials and Methods: In this experimental in vitro study, HELA cells were treated with various concentrations of CHALCONE for 72 hours and cell death rates was evaluated by MTT test. Results were analyzed by Student T-Test and morphological changes were assessed by Acridine orange and propidium iodide (PI) staining.Results: Our results showed that new synthetic CHALCONE in studied concentrations inhibited tumor cell growth. Highest percent (50.44%) of growth inhibition was seen in 40 mg/ml concentration and after 72 hours IC50 was 40mg/ml. morphological changes of HELA cells after 24 hours were also strengthened the probability of cellular apoptosis.Conclusion: The results showed that new CHALCONE has inhibitive effects on HELA tumor cell line and a probable mechanism of apoptosis can causes cellular death.

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APA: Copy

SEYEDALIPOUR, BAGHER, FAZELI, MOGHADASE, AHMADY ASBCHIN, SALMAN, CHESHOMI, HAMID, & ALDAGHI, LEILASADAT. (2015). CYTOTOXICITY EFFECT OF SYNTHETIC CHALCONE DERIVED FROM 4-METHOXYPHENYL ON HELA CELL LINE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 22(5), 919-926. SID. https://sid.ir/paper/81862/en

Vancouver: Copy

SEYEDALIPOUR BAGHER, FAZELI MOGHADASE, AHMADY ASBCHIN SALMAN, CHESHOMI HAMID, ALDAGHI LEILASADAT. CYTOTOXICITY EFFECT OF SYNTHETIC CHALCONE DERIVED FROM 4-METHOXYPHENYL ON HELA CELL LINE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(5):919-926. Available from: https://sid.ir/paper/81862/en

IEEE: Copy

BAGHER SEYEDALIPOUR, MOGHADASE FAZELI, SALMAN AHMADY ASBCHIN, HAMID CHESHOMI, and LEILASADAT ALDAGHI, “CYTOTOXICITY EFFECT OF SYNTHETIC CHALCONE DERIVED FROM 4-METHOXYPHENYL ON HELA CELL LINE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 919–926, 2015, [Online]. Available: https://sid.ir/paper/81862/en

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