INVESTIGATING THE CYTOTOXIC EFFECTS OF A NEW SYNTHETIC CHALCONE DERIVATIVE ON HELA CELL LINE

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SEYEDALIPOUR B.; TAGHAVI Y.; KHALILZADEH M.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:23 | Issue:3 Page(s): 168-178

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Title

INVESTIGATING THE CYTOTOXIC EFFECTS OF A NEW SYNTHETIC CHALCONE DERIVATIVE ON HELA CELL LINE

Author(s)

SEYEDALIPOUR B. | TAGHAVI Y. | KHALILZADEH M. | Issue Writer Certificate

Keywords

CHALCONEQ2

CYTOTOXICITYQ2

HELA CELL LINESQ2

MTT TESTQ1

Abstract

Introduction: CHALCONEs and their derivatives have strong anti-cancer activity. The aim of present study was to evaluate the CYTOTOXICITY effect of new synthetic CHALCONE on Hela cell line.Material &methods: Hela cell line were cultured in RPMI1640 liquid medium along with with 10% inactivated fetal bovine serum (FBS) and antibiotics. Cells were cultured with various concentrations of CHALCONE for 72 hours and were analyzed by using the MTT TEST. Statistical analysis was performed by using of students T-Test. Apoptosis were examined on HELA CELL LINES after 24 hours in concentration of 40 mg/ml CHALCONE by Microscopic method.Findings: The results of this study showed that new synthetic CHALCONE at concentrations of (10, 20, 40, 60, 80, 160 μg/ml) inhibit the growth of Hela cell line 63.75, 56.58, 54.46, 33.60, 18.74, 14.96 after 72 hours, respectively. The highest percentage of growth inhibition at a concentration of 10 mg/ml was 63.753. The IC50 value for Hela cells was 40 mg/ml. Our findings showed that grow the cells have reduced at concentrations of 10 and 20 mg/ml significantly compared to control group after 72 hours.Discussion & Conclusion: Based on our research, synthetic CHALCONE has anti proliferation activity against HeLa cells lines. This activity is related to its effect on cell cycle by inducing G2 / M phase. Further studies are needed to demonstrate the molecular mechanisms of this new CHALCONE

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APA: Copy

SEYEDALIPOUR, B., TAGHAVI, Y., & KHALILZADEH, M.. (2015). INVESTIGATING THE CYTOTOXIC EFFECTS OF A NEW SYNTHETIC CHALCONE DERIVATIVE ON HELA CELL LINE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 23(3), 168-178. SID. https://sid.ir/paper/90304/en

Vancouver: Copy

SEYEDALIPOUR B., TAGHAVI Y., KHALILZADEH M.. INVESTIGATING THE CYTOTOXIC EFFECTS OF A NEW SYNTHETIC CHALCONE DERIVATIVE ON HELA CELL LINE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;23(3):168-178. Available from: https://sid.ir/paper/90304/en

IEEE: Copy

B. SEYEDALIPOUR, Y. TAGHAVI, and M. KHALILZADEH, “INVESTIGATING THE CYTOTOXIC EFFECTS OF A NEW SYNTHETIC CHALCONE DERIVATIVE ON HELA CELL LINE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 3, pp. 168–178, 2015, [Online]. Available: https://sid.ir/paper/90304/en

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