The Expression of Two Homeobox Genes in Breast Cancer

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Adli Abolfazl; Kholdi Solmaz; Behroozikhah Mohammad Reza; FORGHANIFARD MOHAMMAD MAHDI

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Journal: Journal of Sabzevar University of Medical Sciences Year:2019 | Volume:25 | Issue:6 Page(s): 895-902

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Title

The Expression of Two Homeobox Genes in Breast Cancer

Author(s)

Adli Abolfazl | Kholdi Solmaz | Behroozikhah Mohammad Reza | FORGHANIFARD MOHAMMAD MAHDI | Issue Writer Certificate

Keywords

breast cancerQ2

CDX1Q1

CDX2Q1

realtime PCRQ1

Abstract

Introduction: breast cancer is one of the main cause of cancer-related death in women in the world. This cancer is heterogeneous consisting of three types including LCIS (Lobular carcinoma in situ), DCIS (Ductal carcinoma in situ), and invasive carcinoma. Although there are different therapeutic modalities such as chemotherapy and surgery, investigation of the involved molecular mechanisms help to diagnosis the disease at primary stages. In this study, we aimed to analyze the expression of CDX1 and CDX2 in breast cancer. Materials & Methods: In this study, total RNA was extracted from 40 tumor and their corresponded margin normal tissues using RNA extraction kit. After cDNA synthesis with Takara cDNA synthesis kit, expressional analysis of CDX1 and CDX2 gene was evaluated by Real time PCR techniques. Results: The data showed that the expression of CDX1 and CDX2 genes were decreased in breast cancer in 50% and 45%, respectively. Also, statistical analysis demonstrated that the underexpression of CDX1 was correlated with tumor size. Conclusion: To the best our knowledge, this is the first study that shows the reduced expression of these gene in breast cancer. We suggest that these genes may have tumor suppressor role in breast cancer although more studies are needed to show the main mechanism of their role in breast cancer.

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APA: Copy

Adli, Abolfazl, Kholdi, Solmaz, Behroozikhah, Mohammad Reza, & FORGHANIFARD, MOHAMMAD MAHDI. (2019). The Expression of Two Homeobox Genes in Breast Cancer. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(6 ), 895-902. SID. https://sid.ir/paper/81873/en

Vancouver: Copy

Adli Abolfazl, Kholdi Solmaz, Behroozikhah Mohammad Reza, FORGHANIFARD MOHAMMAD MAHDI. The Expression of Two Homeobox Genes in Breast Cancer. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;25(6 ):895-902. Available from: https://sid.ir/paper/81873/en

IEEE: Copy

Abolfazl Adli, Solmaz Kholdi, Mohammad Reza Behroozikhah, and MOHAMMAD MAHDI FORGHANIFARD, “The Expression of Two Homeobox Genes in Breast Cancer,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 6 , pp. 895–902, 2019, [Online]. Available: https://sid.ir/paper/81873/en

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