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Information Journal Paper

Title

THE EFFECT OF HMWCK PROTEIN EXPRESSION AS MARKER IN BENIGN PROSTATIC HYPERPLASIA (BPH) AND ADENOCARCINOMA BY IMMUNOHIDTOCHEMISTERY AN HISTOLOGY METHODS

Pages

  271-278

Abstract

 Background and purposeThe effect of the marker expression high molecular weight cytokeratin (HMWCK (in Benign prostatic hyperplasia (BPH) and ADENOCARCINOMA prostate. There was conventional reported about rate expression HMWCK in ADENOCARCINOMA prostate. The purpose of this studied was to determine expression of the marker HMWCK with histopathological parameters in BPH and adnocarcinoma prostates by IMMUNOHISTOCHEMISTRY methods.Materials & Methods: This descriptive analytical research was conducted on 79 patients admitted to Hospital in Isfahan Iran. Samples were fixed in formalin and tissue processing and stained by hematoxilin and eosin ADENOCARCINOMA samples were classified with Gleason pattern (score) method by pathologist. The effect of over expression in marker expression HMWCK was done after diagnosis by two expert (blind). The obtained data were analyzed using chi-square test.Results: Out of the 79 specimens 43 samples were BPH and 36 samples were ADENOCARCINOMA.40 samples with diagnosis BPH were observed of the marker HMWCK and 3 samples were negative. Out of 36 samples with diagnosis ADENOCARCINOMA, 35 over expression marker of the HMWCK were negative but one samples was positive. The over specimens malignancy were in higher Gleason score. There was significant relationships between type samples (BPH and ADENOCARCINOMA) with over expression of the marker HMWCK p<0.001.Conclusion: Our study to showed that usage of the marker HMWCK could be differentiated to increase diagnosis BPH tissue from cancer, therefore utilize of the marker HMWCK for prognosis prostate disease could be aided and benefit.

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    APA: Copy

    GOLMOHAMMADI, RAHIM, MOHAGERI, MOHAMMAD REZA, & GOLMOHAMMADI, MOTAHAREH. (2018). THE EFFECT OF HMWCK PROTEIN EXPRESSION AS MARKER IN BENIGN PROSTATIC HYPERPLASIA (BPH) AND ADENOCARCINOMA BY IMMUNOHIDTOCHEMISTERY AN HISTOLOGY METHODS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(3 ), 271-278. SID. https://sid.ir/paper/81911/en

    Vancouver: Copy

    GOLMOHAMMADI RAHIM, MOHAGERI MOHAMMAD REZA, GOLMOHAMMADI MOTAHAREH. THE EFFECT OF HMWCK PROTEIN EXPRESSION AS MARKER IN BENIGN PROSTATIC HYPERPLASIA (BPH) AND ADENOCARCINOMA BY IMMUNOHIDTOCHEMISTERY AN HISTOLOGY METHODS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(3 ):271-278. Available from: https://sid.ir/paper/81911/en

    IEEE: Copy

    RAHIM GOLMOHAMMADI, MOHAMMAD REZA MOHAGERI, and MOTAHAREH GOLMOHAMMADI, “THE EFFECT OF HMWCK PROTEIN EXPRESSION AS MARKER IN BENIGN PROSTATIC HYPERPLASIA (BPH) AND ADENOCARCINOMA BY IMMUNOHIDTOCHEMISTERY AN HISTOLOGY METHODS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 3 , pp. 271–278, 2018, [Online]. Available: https://sid.ir/paper/81911/en

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