INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

DIVSALAR ADELEH; BEHROOZI JAVAD; SABOURY ALI AKBAR

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2014 | Volume:21 | Issue:3 Page(s): 482-492

Download Full-Text

Persian Verion

View:

2,469

Download:

Cites:

Information Journal Paper

Title

INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS

Author(s)

DIVSALAR ADELEH | BEHROOZI JAVAD | SABOURY ALI AKBAR | Issue Writer Certificate

Keywords

DIABETESQ2

GLYCATIONQ2

BEE VENOMQ2

ASPIRINQ2

Abstract

Background: DIABETES is one of the most common endocrine disorders. In this disease due to increased blood glucose levels, protein GLYCATION increases. Protein GLYCATION in DIABETES leads to irreparable consequences. The aim of this study was to investigate the synergic effect of BEE VENOM and ASPIRIN on human hemoglobin GLYCATION in the presence of glucose.Materials and Methods: In this experimental study, hemoglobin (10 mg/ml) was incubated in the presence and absence of glucose (40 mM), ASPIRIN (2.5 mM) and BEE VENOM (in different concentrations of 10, 20 and 40 μg/ml) for 5 weeks. Amount of hemoglobin GLYCATION was evaluated via investigation of changes in soret band, amount of hemoglobin heme degradation and alteration in secondary structure of protein using UV-visible spectroscopy, fluorometry and Circular Dichroism Spectropolarimetry methods. The data were analyzed using In Stat 3 software and statistical tests including one way variance analysis and Turkey test. P values less than 0.05 were considered significant.Results: Hemoglobin incubation in the presence of glucose led to reduction of soret band absorption, degradation of heme and increment of beta sheet value in secondary structure of hemoglobin. Simultaneous presence of BEE VENOM and ASPIRIN reduced the rate of heme degradation (p<0.001) up to 36%, and the beta sheet formation up to 54% (p<0.001). Also, the amount of structural alteration and hemoglobin GLYCATION significantly decreased.Conclusion: BEE VENOM and ASPIRIN have significant antiglycation properties and simultaneous use of them can decrease protein GLYCATION.

Cites

No record.

References

No record.

Cite

APA: Copy

DIVSALAR, ADELEH, BEHROOZI, JAVAD, & SABOURY, ALI AKBAR. (2014). INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 21(3), 482-492. SID. https://sid.ir/paper/82054/en

Vancouver: Copy

DIVSALAR ADELEH, BEHROOZI JAVAD, SABOURY ALI AKBAR. INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;21(3):482-492. Available from: https://sid.ir/paper/82054/en

IEEE: Copy

ADELEH DIVSALAR, JAVAD BEHROOZI, and ALI AKBAR SABOURY, “INVESTIGATING THE SYNERGIC EFFECT OF BEE VENOM AND ASPIRIN ON INHIBITION OF GLYCATION IN DIABETIC CONDITIONS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 3, pp. 482–492, 2014, [Online]. Available: https://sid.ir/paper/82054/en

Related Journal Papers