THE MACROSCOPIC AND MICROSCOPIC EFFECTS OF ASCORBIC ACID ON THE KIDNEY OF MALE RABBITS EXPOSED TO LEAD

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GOLMOHAMMADI RAHIM; DASHTI GH.R.; VAHEDI P.

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Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2008 | Volume:15 | Issue:1 (47) Page(s): 14-19

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Title

THE MACROSCOPIC AND MICROSCOPIC EFFECTS OF ASCORBIC ACID ON THE KIDNEY OF MALE RABBITS EXPOSED TO LEAD

Author(s)

GOLMOHAMMADI RAHIM | DASHTI GH.R. | VAHEDI P. | Issue Writer Certificate

Keywords

LEADQ2

KIDNEYSQ2

ASCORBIC ACIDQ3

Abstract

Background and Purpose: Technological Progress and urbanization have caused LEAD pollution in air water and earth and higher LEAD intakes into the body have renal and nervous disorders. Since ASCORBIC ACID acts as a can antioxidant can it reduce the toxic effects of LEAD in KIDNEYS? In order to answer this question this study was designed to investigate the macroscopic and microscopic effects of ASCORBIC ACID on the kidney of male rabbits exposed to LEAD.Methods and Materials: This experimental research was conducted on 40 white male rabbits at Isfahan University of Medical Sciences Iran. After adapting to the new environment rabbits were randomly assigned into four groups of ten: a control group exclusive ASCORBIC ACID group exclusive LEAD group and the fourth group receiving both LEAD and ASCORBIC ACID. After a 40-day diet they were anaesthetized by pentobarbital and their KIDNEYS were extracted. Tissue processing was conducted after KIDNEYS were weighed and measured. Also five-micron sections were prepared through serial sections stained with H&E. The slides were studied using a light microscope. ANOVA and t-test were used in data analysis.Results: Mean weight and dimension of the KIDNEYS were not significantly different across the four groups. Proximal convoluted tubules were observed in the exclusive LEAD group but not in other three groups.Conclusion: ASCORBIC ACID was effective in reducing the toxic effects of LEAD on kidney tissues.

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References

LEAD DETECTION IN BREAD INGREDIENTS OF THE FIFTH DISTRICT OF SHIRAZ CITY IN 2000

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APA: Copy

GOLMOHAMMADI, RAHIM, DASHTI, GH.R., & VAHEDI, P.. (2008). THE MACROSCOPIC AND MICROSCOPIC EFFECTS OF ASCORBIC ACID ON THE KIDNEY OF MALE RABBITS EXPOSED TO LEAD. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 15(1 (47)), 14-19. SID. https://sid.ir/paper/82404/en

Vancouver: Copy

GOLMOHAMMADI RAHIM, DASHTI GH.R., VAHEDI P.. THE MACROSCOPIC AND MICROSCOPIC EFFECTS OF ASCORBIC ACID ON THE KIDNEY OF MALE RABBITS EXPOSED TO LEAD. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;15(1 (47)):14-19. Available from: https://sid.ir/paper/82404/en

IEEE: Copy

RAHIM GOLMOHAMMADI, GH.R. DASHTI, and P. VAHEDI, “THE MACROSCOPIC AND MICROSCOPIC EFFECTS OF ASCORBIC ACID ON THE KIDNEY OF MALE RABBITS EXPOSED TO LEAD,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 1 (47), pp. 14–19, 2008, [Online]. Available: https://sid.ir/paper/82404/en

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