PROTECTIVE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF SAFFRON ON LIVER ENZYMES (AST,ALT,ALP) BY HYPERVITAMINOSIS A IN MALE RAT.

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOKHTARI MOKHTAR; SHARIATI MEHRDAD; AJDARI DORNA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Sabzevar University of Medical Sciences Year:2013 | Volume:20 | Issue:2 (68) Page(s): 133-141

Download Full-Text

Persian Verion

View:

1,003

Download:

Cites:

Information Journal Paper

Title

PROTECTIVE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF SAFFRON ON LIVER ENZYMES (AST,ALT,ALP) BY HYPERVITAMINOSIS A IN MALE RAT.

Author(s)

MOKHTARI MOKHTAR | SHARIATI MEHRDAD | AJDARI DORNA | Issue Writer Certificate

Keywords

SAFFRONQ2

VITAMIN AQ3

ASTQ2

ALTQ2

ALPQ2

RATQ2

Abstract

Introduction and Aim: Nowedays VITAMIN A consumption to compensate for the lack of it in the body or healing of skin disorders without considering respective side effects is so common. In this research the protective effect of SAFFRON hydro alcoholic extracts on liver enzymes following VITAMIN A toxicity was investigated.Materials and Methods: In the experimental study 48 RATs were divided into 6 groups of 8, namely control, sham and 4experimental.Control group didn’t received anythings, sham group received only distilled water. The experimental group1 Number1 received SAFFRON hydro alcoholic extract with 50mg/kg dose for 15 days. Experimental groups 3, 4, 5, initially received VITAMIN A 50000IU for 15 days. The experimental groups 4, 5 received SAFFRON hydro alcoholic extract with 50, 80 (mg/kg) dose for 15 days. At the end of this period, blood was collected from the hearts for measuring the amounts of AST, ALT and ALP. Obtained data were statistically analyzed using statistical tests including one way variance analysis and tukey test. P<0.05 was considered significant.Results: Levels of AST, ALT, ALP in the experimental group 1 that received only the extracts with 50 mg/kg dose didn't exhibit any change in comparison with control and sham group (P<0.05). In the experimental group2 that received only VITAMIN A was observed a dramatic difference in the enzymes in comparison compare with control and sham groups. In the experimental group 3 that received VITAMIN A plus SAFFRON hydro alcoholic extracts with 50 mg/kg dose, there wasn't any significant difference in the mentioned liver enzymes, in comparison with the experimental group 2 (P<0.05).In the experimental group 4 that received VITAMIN A plus SAFFRON hydro alcoholic extracts with 80 mg/kg dose, the level of AST, ALT.ALP in comparison with experimental group 2 that received only VITAMIN A show significan difference (P<0.05).Conclusion: Considering the present fidings, SAFFRON extracts seems to protect hepatocytes against oxidative stress caused by hypervitaminosis A due to its antioxidant compounds.

Cites

Effect of Barberry juice consumption on serum levels of liver enzymes following exhaustive exercise in active girls

References

No record.

Cite

APA: Copy

MOKHTARI, MOKHTAR, SHARIATI, MEHRDAD, & AJDARI, DORNA. (2013). PROTECTIVE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF SAFFRON ON LIVER ENZYMES (AST,ALT,ALP) BY HYPERVITAMINOSIS A IN MALE RAT.. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 20(2 (68)), 133-141. SID. https://sid.ir/paper/82445/en

Vancouver: Copy

MOKHTARI MOKHTAR, SHARIATI MEHRDAD, AJDARI DORNA. PROTECTIVE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF SAFFRON ON LIVER ENZYMES (AST,ALT,ALP) BY HYPERVITAMINOSIS A IN MALE RAT.. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;20(2 (68)):133-141. Available from: https://sid.ir/paper/82445/en

IEEE: Copy

MOKHTAR MOKHTARI, MEHRDAD SHARIATI, and DORNA AJDARI, “PROTECTIVE EFFECT OF HYDRO-ALCOHOLIC EXTRACTS OF SAFFRON ON LIVER ENZYMES (AST,ALT,ALP) BY HYPERVITAMINOSIS A IN MALE RAT.,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 20, no. 2 (68), pp. 133–141, 2013, [Online]. Available: https://sid.ir/paper/82445/en

Related Journal Papers