DETECTION OF BCL-2 TRANSLOCATION IN PANCREATIC CANCER IN IRANIAN PATIENTS

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GORDEHIE SUSAN; Sheikhnejad Reza; ANGAJI SEYED ABDOLHAMID; KHANAKI MAHMOUD; MARANDI VAHID

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Journal: Journal of Sabzevar University of Medical Sciences Year:2018 | Volume:25 | Issue:1 Page(s): 61-68

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Title

DETECTION OF BCL-2 TRANSLOCATION IN PANCREATIC CANCER IN IRANIAN PATIENTS

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Keywords

APOPTOSISQ3

BCL-2 TRANSLOCATIONQ1

PANCREATIC CANCERQ1

PARAFFIN EMBEDDED TISSUEQ1

PERSONALIZED TREATMENTQ2

POLYMERASE CHAIN REACTIONQ2

Abstract

Backgrond: PANCREATIC CANCER is one of the most leading causes of cancer-related deaths. Considering the role of Bcl-2 family gene in APOPTOSIS that are known to be over-expressed in most cancers, this study focused on the detection of BCL-2 TRANSLOCATION t (14; 18) to the immunoglobulin heavy chain (IgH) that may contribute to the pathogenesis of PANCREATIC CANCER. Materials and Methods: Forty-nine samples of PARAFFIN EMBEDDED TISSUEs (extracted from 1537 slides of 105 patients in one of the major local cancer centers) were investigated for detection of BCL-2 TRANSLOCATION t (14; 18) by standard PCR.Results: The Bcl-2 t (14; 18) translocation was detected in 23 of all 49 patients (46.9%), including 10 of 23 translocated patients (43%) with break points within the mbr cluster, 11 with involvement of the mcr locus (48%), and 2 in the icr locus (9%).Conclusion: Detection of Bcl2 translocation in PANCREATIC CANCER is in agreement with results from other studies, and shows this rearrangement could be considered as a new treatment strategy based on APOPTOSIS or PERSONALIZED TREATMENT.

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APA: Copy

GORDEHIE, SUSAN, Sheikhnejad, Reza, ANGAJI, SEYED ABDOLHAMID, KHANAKI, MAHMOUD, & MARANDI, VAHID. (2018). DETECTION OF BCL-2 TRANSLOCATION IN PANCREATIC CANCER IN IRANIAN PATIENTS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 25(1 ), 61-68. SID. https://sid.ir/paper/82512/en

Vancouver: Copy

GORDEHIE SUSAN, Sheikhnejad Reza, ANGAJI SEYED ABDOLHAMID, KHANAKI MAHMOUD, MARANDI VAHID. DETECTION OF BCL-2 TRANSLOCATION IN PANCREATIC CANCER IN IRANIAN PATIENTS. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;25(1 ):61-68. Available from: https://sid.ir/paper/82512/en

IEEE: Copy

SUSAN GORDEHIE, Reza Sheikhnejad, SEYED ABDOLHAMID ANGAJI, MAHMOUD KHANAKI, and VAHID MARANDI, “DETECTION OF BCL-2 TRANSLOCATION IN PANCREATIC CANCER IN IRANIAN PATIENTS,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 1 , pp. 61–68, 2018, [Online]. Available: https://sid.ir/paper/82512/en

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