ASSOCIATION OF IGF-1 GENE (RS5742612) POLYMORPHISM WITH COLORECTAL CANCER

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ARKANI M.; SAFAEI A.; KARIMI KH.; VAHEDI M.; MOHEBI R.; FATEMI F.; VAFAEE M.; ZALI M.R.

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Journal: Journal of Sabzevar University of Medical Sciences Year:2012 | Volume:19 | Issue:2 (64) Page(s): 109-115

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Title

ASSOCIATION OF IGF-1 GENE (RS5742612) POLYMORPHISM WITH COLORECTAL CANCER

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Keywords

POLYMORPHISMQ2

INSULIN- LIKE GROWTH FACTORQ2

COLORECTAL NEOPLASMSQ2

Abstract

Background: Insulin-like growth factor 1 has an important role in cell proliferation and growth. POLYMORPHISM in IGF-1 gene changes the level of this hormone and increases the risk of colorectal cancer. The aim of this study is to assess the incidence of IGF-1 POLYMORPHISM rs5742612 in Iranian population and to investigate the influence of this POLYMORPHISM in increasing the risk of colorectal cancer.Methods: Genotyping of IGF-1 gene was performed in a series of 110 colorectal cancer patients and 110 controls by using polymerase chain reaction and restriction fragment length POLYMORPHISM genotyping (PCR-RFLP) assays. We calculated odds ratio and confidence interval (CI) of IGF-1 genotypes to determine if these POLYMORPHISMs are associated with colorectal cancer.Result: No significant association was found between POLYMORPHISM of IGF-1 gene (rs5742612) and increased risk of colorectal cancer (p=0.92). The odds ratio for the heterozygous genotype CT versus the normal genotype CC was 1.3 (95% CI: 0.3-6.27) and the odds ratio for the mutant genotype TT versus the normal genotype CC was 0.0. The frequency of the mutant allele was 2.5%.Conclusion: These findings suggest that IGF-1 rs5742612 POLYMORPHISM is not associated with increased risk of colorectal cancer.

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APA: Copy

ARKANI, M., SAFAEI, A., KARIMI, KH., VAHEDI, M., MOHEBI, R., FATEMI, F., VAFAEE, M., & ZALI, M.R.. (2012). ASSOCIATION OF IGF-1 GENE (RS5742612) POLYMORPHISM WITH COLORECTAL CANCER. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 19(2 (64)), 109-115. SID. https://sid.ir/paper/82549/en

Vancouver: Copy

ARKANI M., SAFAEI A., KARIMI KH., VAHEDI M., MOHEBI R., FATEMI F., VAFAEE M., ZALI M.R.. ASSOCIATION OF IGF-1 GENE (RS5742612) POLYMORPHISM WITH COLORECTAL CANCER. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;19(2 (64)):109-115. Available from: https://sid.ir/paper/82549/en

IEEE: Copy

M. ARKANI, A. SAFAEI, KH. KARIMI, M. VAHEDI, R. MOHEBI, F. FATEMI, M. VAFAEE, and M.R. ZALI, “ASSOCIATION OF IGF-1 GENE (RS5742612) POLYMORPHISM WITH COLORECTAL CANCER,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 2 (64), pp. 109–115, 2012, [Online]. Available: https://sid.ir/paper/82549/en

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