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Information Journal Paper

Title

ASSOCIATION OF INTERLEUKIN-22 GENE POLYMORPHISM (RS1179251) AND COLORECTAL CANCER RISK IN THE IRANIAN POPULATION

Pages

  1-5

Abstract

 Background: INTERLEUKIN-22 (IL-22) is recognized as a key factor in chronic inflammatory disorders. Chronic inflammation is one of the major causes of CRC. Therefore POLYMORPHISMs occur in the inflammatory genes could modulate the levels of disease. We have investigated the association between single nucleotide POLYMORPHISM (SNP) in IL-22 gene (rs1179251) and CRC risk in the Iranian population.Materials and Methods: This case- control study was done on 166 CRC patients and and 236 health control subjects. Genomic DNA is isolated from peripheral blood leukocytes by salting out method and was genotyped using polymerase chain reaction and restriction fragment length POLYMORPHISM (PCR-RFLP).Results: The frequencies of GG, GC, CC genotypes in case and control groups were 71.7%, 25.3%, 3.0% and 69.5%, 26.7%, 3.8%, respectively. No significant association was found between IL-22 gene POLYMORPHISM and risk of developing CRC (p=0.85).Conclusion: Our data suggest that rs1179246 in IL-22 gene was not associated with the CRC susceptibility in the Iranian population.

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    APA: Copy

    MOHEBI, SEYED REZA, KARIMI, KHATOON, ROSTAMI, FATEMEH, TAHAEI, SEYED MOHAMMAD EBRAHIM, AZIMZADEH, PEDRAM, ROMANI, SARA, MIRTALEBI, HANIE, & ZALI, MOHAMMAD REZA. (2014). ASSOCIATION OF INTERLEUKIN-22 GENE POLYMORPHISM (RS1179251) AND COLORECTAL CANCER RISK IN THE IRANIAN POPULATION. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, 23(1 (SUPP.)), 1-5. SID. https://sid.ir/paper/98495/en

    Vancouver: Copy

    MOHEBI SEYED REZA, KARIMI KHATOON, ROSTAMI FATEMEH, TAHAEI SEYED MOHAMMAD EBRAHIM, AZIMZADEH PEDRAM, ROMANI SARA, MIRTALEBI HANIE, ZALI MOHAMMAD REZA. ASSOCIATION OF INTERLEUKIN-22 GENE POLYMORPHISM (RS1179251) AND COLORECTAL CANCER RISK IN THE IRANIAN POPULATION. MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY[Internet]. 2014;23(1 (SUPP.)):1-5. Available from: https://sid.ir/paper/98495/en

    IEEE: Copy

    SEYED REZA MOHEBI, KHATOON KARIMI, FATEMEH ROSTAMI, SEYED MOHAMMAD EBRAHIM TAHAEI, PEDRAM AZIMZADEH, SARA ROMANI, HANIE MIRTALEBI, and MOHAMMAD REZA ZALI, “ASSOCIATION OF INTERLEUKIN-22 GENE POLYMORPHISM (RS1179251) AND COLORECTAL CANCER RISK IN THE IRANIAN POPULATION,” MEDICAL SCIENCES JOURNAL OF ISLAMIC AZAD UNIVERSITY, vol. 23, no. 1 (SUPP.), pp. 1–5, 2014, [Online]. Available: https://sid.ir/paper/98495/en

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