THE EFFECT OF VITAMIN C ON EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MALE MICE

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ABBASI MALEKI S.; NAJAFI GH.; EFTEKHARI S.K.

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Title

THE EFFECT OF VITAMIN C ON EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MALE MICE

Author(s)

ABBASI MALEKI S. | NAJAFI GH. | EFTEKHARI S.K. | Issue Writer Certificate

Keywords

ASCORBIC ACIDQ3

MORPHINEQ2

CONDITIONINGQ3

MICEQ2

Abstract

Background and purpose: Dopaminergic and glutamatergic systems play a critical role in expression of MORPHINE-induced place CONDITIONING, while vitamin C, released from glutamatergic neurons, modulates the synaptic action of dopamine and glutamate. This study investigated the effect of vitamin C on expression of MORPHINE-induced place CONDITIONING in male MICE.Materials and methods: In this experimental study, 96 male NMRI MICE (20-30g) were randomly divided into 12 groups of 8: control groups received normal saline (10 ml/kg) and treatment groups received MORPHINE (2.5, 5, and 10 mg/kg) and vitamin C (1, 5, and 30 mg/kg) alone and with MORPHINE. The study took place on six consecutive days, consisting of three phases: preconditioning, CONDITIONING, and postconditioning. In the first set, vitamin C alone were administered in CONDITIONING and postconditioning phases to see if they induced conditioned place preference (CPP) or aversion (CPA). In the second set, MICE received vitamin C in postconditioning phase after CONDITIONING with MORPHINE.Results: Different doses of MORPHINE (5 and 10 mg/kg, p<0.001) induced CPP (112.06±14.44 and 128.65±16.12 sec, respectively) compared to control group (-9.34±2.04 sec). Different doses of vitamin C alone did not induce any significant CPP or CPA.However, coadministration of vitamin C (5 and 30 mg/kg; p<0.01 and p<0.001, respectively) with MORPHINE (5 mg/kg) significantly induced MORPHINE-like CPP (80.4±9.61 and 56.45±13.52 sec, respectively(.Conclusion: Low doses of vitamin C induced MORPHINE-like CPP probably by agonistic action on dopaminergic and glutamatergic systems. Therefore, this vitamin may be useful for controlling compulsive drug-seeking behavior in MORPHINE addicts.

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APA: Copy

ABBASI MALEKI, S., NAJAFI, GH., & EFTEKHARI, S.K.. (2012). THE EFFECT OF VITAMIN C ON EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MALE MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, 19(2 (64)), 164-172. SID. https://sid.ir/paper/82555/en

Vancouver: Copy

ABBASI MALEKI S., NAJAFI GH., EFTEKHARI S.K.. THE EFFECT OF VITAMIN C ON EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MALE MICE. JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2012;19(2 (64)):164-172. Available from: https://sid.ir/paper/82555/en

IEEE: Copy

S. ABBASI MALEKI, GH. NAJAFI, and S.K. EFTEKHARI, “THE EFFECT OF VITAMIN C ON EXPRESSION OF MORPHINE-INDUCED CONDITIONED PLACE PREFERENCE IN MALE MICE,” JOURNAL OF SABZEVAR UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 2 (64), pp. 164–172, 2012, [Online]. Available: https://sid.ir/paper/82555/en

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