THE INTERACTION OF MORPHINE, GLUCOSE AND ATP SENSITIVE POTASSIUM CHANNELS ON THE CONSOLIDATION OF MORPHINE INDUCED PLACE PREFERENCE

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SATARI NAEINI M.; ORYAN SHAHRBANOU; BABAPOUR V.; ALIBALAIE M.

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Journal: ADVANCES IN COGNITIVE SCIENCE Year:2006 | Volume:8 | Issue:1 Page(s): 9-16

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Title

THE INTERACTION OF MORPHINE, GLUCOSE AND ATP SENSITIVE POTASSIUM CHANNELS ON THE CONSOLIDATION OF MORPHINE INDUCED PLACE PREFERENCE

Author(s)

SATARI NAEINI M. | ORYAN SHAHRBANOU | BABAPOUR V. | ALIBALAIE M. | Issue Writer Certificate

Keywords

MORPHINEQ3

POTASSIUM CHANNELQ3

CONDITIONAL PLACE PREFERENCEQ3

Abstract

Objective: In the present study interaction of glucose and ATP sensitive POTASSIUM CHANNELs on the consolidation of MORPHINE induced place preference in male mice has been investigated.Material and Methods: Conditioned place preference method was used to assess MORPHINE reward and effects of glucose ,glibenclamide and diazoxide on it. Results: Intraperitoneal administration of different doses of MORPHINE sulphate (0.5-7.5 mg/kg IP) produced a dose-dependent conditioned place preference (cpp). However, the isolated administration of different doses of glibenclamide (3,6 AND12mg/kg IP), diazoxide (15, 30 and 60mg/kg IP) and glucose (100, 200, 500, 2000 mg/kg) did not produce such an effect. The injection of glucose (2000 mg/kg IP) and glibenclamide (6 mg/kg IP) produced significant MORPHINE (0.5 mg/kg IP) induced cpp. Also, the response of glibenclamide (6mg/kg IP) was attenuated by diazoxide (60 mg /kg IP). However, this dose of diazoxide alone had no effect on MORPHINE (0.5 mg/kg IP) induced cpp .Injection of different doses of diazoxide (15, 30 and 60mg/kg IP), glibenclamide (3, 6 and 12mg/kg IP) and MORPHINE (0.5-7.5 mg/kg) did not effect blood glucose level. Conclusion: It is concluded that glucose may be involved in MORPHINE induced conditioned place preference through KATP channels.

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APA: Copy

SATARI NAEINI, M., ORYAN, SHAHRBANOU, BABAPOUR, V., & ALIBALAIE, M.. (2006). THE INTERACTION OF MORPHINE, GLUCOSE AND ATP SENSITIVE POTASSIUM CHANNELS ON THE CONSOLIDATION OF MORPHINE INDUCED PLACE PREFERENCE. ADVANCES IN COGNITIVE SCIENCE, 8(1), 9-16. SID. https://sid.ir/paper/82944/en

Vancouver: Copy

SATARI NAEINI M., ORYAN SHAHRBANOU, BABAPOUR V., ALIBALAIE M.. THE INTERACTION OF MORPHINE, GLUCOSE AND ATP SENSITIVE POTASSIUM CHANNELS ON THE CONSOLIDATION OF MORPHINE INDUCED PLACE PREFERENCE. ADVANCES IN COGNITIVE SCIENCE[Internet]. 2006;8(1):9-16. Available from: https://sid.ir/paper/82944/en

IEEE: Copy

M. SATARI NAEINI, SHAHRBANOU ORYAN, V. BABAPOUR, and M. ALIBALAIE, “THE INTERACTION OF MORPHINE, GLUCOSE AND ATP SENSITIVE POTASSIUM CHANNELS ON THE CONSOLIDATION OF MORPHINE INDUCED PLACE PREFERENCE,” ADVANCES IN COGNITIVE SCIENCE, vol. 8, no. 1, pp. 9–16, 2006, [Online]. Available: https://sid.ir/paper/82944/en

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