ANXIETY-RELATED BEHAVIORS INDUCED BY HISTAMINE IN MORPHINE SENSITIZED RATS

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KHODARAHMI P.; ORYAN SHAHRBANOU; REZAYOF A.; ZARINDAST M.R.

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Journal: ADVANCES IN COGNITIVE SCIENCE Year:2008 | Volume:10 | Issue:2 (38) Page(s): 61-68

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Title

ANXIETY-RELATED BEHAVIORS INDUCED BY HISTAMINE IN MORPHINE SENSITIZED RATS

Author(s)

KHODARAHMI P. | ORYAN SHAHRBANOU | REZAYOF A. | ZARINDAST M.R. | Issue Writer Certificate

Keywords

SENSITIZATIONQ3

HISTAMINEQ3

MORPHINEQ3

NALOXANEQ3

ANXIETYQ2

PLUS-MAZ TESTQ2

RATQ2

Abstract

Objective: In the present study, the effect of bilateral intrahippocampal administration of HISTAMINE on ANXIETY-related behavior in RATs was investigated. Method: The RATs were first sensitized through 3 days of MORPHINE administration and a 5 day drug-free period. The animals were then examined in a plus shaped maze. Results: Intra-VHC bilateral administration of HISTAMINE decreased %OAT (Open Arm Times) and %OAE(Open Arm Entries) but not locomotor activity, thus showing an anxiogenic response. However, the administration of HISTAMINE to MORPHINE-sensitized RATs increased OAT and OAE in comparison with saline administered groups, which is indicative of a decrease in ANXIETY in the sensitized animals. Conclusion: Bilateral administration of HISTAMINE in ventral hippocampus induces an anxiogenic effect, which decreases in MORPHINE sensitized RATs NALOXANE antagonizes the effects of MORPHINE on ANXIETY.

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References

INFLUENCE OF MORPHINE-OR APOMORPHINE-INDUCED SENSITIZATION ON HISTAMINE STATE-DEPENDENT LEARNING

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APA: Copy

KHODARAHMI, P., ORYAN, SHAHRBANOU, REZAYOF, A., & ZARINDAST, M.R.. (2008). ANXIETY-RELATED BEHAVIORS INDUCED BY HISTAMINE IN MORPHINE SENSITIZED RATS. ADVANCES IN COGNITIVE SCIENCE, 10(2 (38)), 61-68. SID. https://sid.ir/paper/82985/en

Vancouver: Copy

KHODARAHMI P., ORYAN SHAHRBANOU, REZAYOF A., ZARINDAST M.R.. ANXIETY-RELATED BEHAVIORS INDUCED BY HISTAMINE IN MORPHINE SENSITIZED RATS. ADVANCES IN COGNITIVE SCIENCE[Internet]. 2008;10(2 (38)):61-68. Available from: https://sid.ir/paper/82985/en

IEEE: Copy

P. KHODARAHMI, SHAHRBANOU ORYAN, A. REZAYOF, and M.R. ZARINDAST, “ANXIETY-RELATED BEHAVIORS INDUCED BY HISTAMINE IN MORPHINE SENSITIZED RATS,” ADVANCES IN COGNITIVE SCIENCE, vol. 10, no. 2 (38), pp. 61–68, 2008, [Online]. Available: https://sid.ir/paper/82985/en

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