THE EFFECT OF NICOTINIC RECEPTORS OF DORSAL HIPPOCAMPUS ON PSYCHOLOGICAL DEPENDENCE IN WISTAR RATS

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ZAT ALI H.; REZAYOF A.; ZARINDAST M.R.; HAERI ROUHANI SEYED ALI; RAZAVI MOVAHED S.

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Journal: Advances in Cognitive Sciences Year:2007 | Volume:9 | Issue:2 (34) Page(s): 1-11

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Title

THE EFFECT OF NICOTINIC RECEPTORS OF DORSAL HIPPOCAMPUS ON PSYCHOLOGICAL DEPENDENCE IN WISTAR RATS

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Keywords

MORPHINEQ3

NICOTINIC RECEPTOR AGONIST AND ANTAGONISTQ3

CONDITIONED PLACE PREFERENCEQ3

DORSAL HIPPOCAMPUSQ3

RATQ3

Abstract

Objective: In this study, the effects of bilateral injections of nicotinic cholinergic agents into the hippocampal CA1 region of Wistar RATs on MORPHINE-induced CONDITIONED PLACE PREFERENCE (CPP) was studied.Method: All animals were canulated in the CA1 area of DORSAL HIPPOCAMPUS by stereotaxic instrument. Each animal was allowed to recover 1-week before CPP induction. We used a 5-day schedule for CPP with three distinct phases: first, the preconditioning phase, second, the conditioning phase and finally, the testing or the expression phase.Results: Subcutaneous administration of different doses of MORPHINE sulphate (0.5-6mg/kg) produced a dose-dependent CPP. Using a 3-day schedule of conditioning, it was found that intra-CA1 administration of nicotine (0.5, 0.75, and 1mg/rat) with an ineffective dose of MORPHINE (0.5mg/kg) elicited a significant CPP. Bilateral injections of different doses of the nicotinic receptor antagonist, mecamylamine (2, 4, and 8mg/rat) into the CA1 regions significantly inhibited the MORPHINE (6mg/kg)-induced CPP. Moreover mecamylamine (8mg/rat, intra-CA1) decreased the effect of nicotine-induced potentiation of the MORPHINE response.Conclusion: Intra-CA1 injections of nicotine or mecamylamine alone did not induce a significant place preference or place aversion. It may be concluded that the nicotinic receptors of the hippocampal CA1 regions play an important role in MORPHINE reward.

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APA: Copy

ZAT ALI, H., REZAYOF, A., ZARINDAST, M.R., HAERI ROUHANI, SEYED ALI, & RAZAVI MOVAHED, S.. (2007). THE EFFECT OF NICOTINIC RECEPTORS OF DORSAL HIPPOCAMPUS ON PSYCHOLOGICAL DEPENDENCE IN WISTAR RATS. ADVANCES IN COGNITIVE SCIENCE, 9(2 (34)), 1-11. SID. https://sid.ir/paper/83074/en

Vancouver: Copy

ZAT ALI H., REZAYOF A., ZARINDAST M.R., HAERI ROUHANI SEYED ALI, RAZAVI MOVAHED S.. THE EFFECT OF NICOTINIC RECEPTORS OF DORSAL HIPPOCAMPUS ON PSYCHOLOGICAL DEPENDENCE IN WISTAR RATS. ADVANCES IN COGNITIVE SCIENCE[Internet]. 2007;9(2 (34)):1-11. Available from: https://sid.ir/paper/83074/en

IEEE: Copy

H. ZAT ALI, A. REZAYOF, M.R. ZARINDAST, SEYED ALI HAERI ROUHANI, and S. RAZAVI MOVAHED, “THE EFFECT OF NICOTINIC RECEPTORS OF DORSAL HIPPOCAMPUS ON PSYCHOLOGICAL DEPENDENCE IN WISTAR RATS,” ADVANCES IN COGNITIVE SCIENCE, vol. 9, no. 2 (34), pp. 1–11, 2007, [Online]. Available: https://sid.ir/paper/83074/en

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