ANALYSIS OF GROSS ANATOMICAL PARAMETERS OF KIDNEY IN MALE RATS FOLLOWING LEAD POISONING BY USING A STEREOLOGICAL METHOD

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HEIDARI Z.; MAHMOUDZADEH SAGHEB H.R.; RAFIGHDOUST H.; MOIEN A.A.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2003 | Volume:5 | Issue:2 Page(s): 123-134

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Title

ANALYSIS OF GROSS ANATOMICAL PARAMETERS OF KIDNEY IN MALE RATS FOLLOWING LEAD POISONING BY USING A STEREOLOGICAL METHOD

Author(s)

HEIDARI Z. | MAHMOUDZADEH SAGHEB H.R. | RAFIGHDOUST H. | MOIEN A.A. | Issue Writer Certificate

Keywords

LEADQ2

STEREO LOGYQ3

GROSS ANATOMYQ4

KIDNEYQ2

RATQ2

Abstract

LEAD is one of the heavy metals, which has adverse effects on renal function and driving to nephropathy. The aim of present experiment was to surveyed changes in gross anatomic parameters of KIDNEY following LEAD poisoning by an unbiased stereological technique. In this experimental study 66 male adult Wistar RATs selected randomly and divided into 6 groups, 3 control and 3 administration groups (n=11). Administration groups received a solution of 0.13% LEAD acetate as drinking water for a period of 4, 8 and 12 weeks respectively. Simultaneously controls received distilled water at the same periods respectively. There after at the end of each period KIDNEY dissected and after fixation in Lilie’s solution, embedded in 7% agar, sectioned into 1 millimeter slices by means of a tissue slicer. Then stereological analysis includes determining total volume of KIDNEY, volume of renal cortex and medulla performed by a method based on Cavalier’s principle. Data were analyzed by oneway ANOVA and differences between groups less than 0.05 considered significant. There was an increase in mean total volume of KIDNEY in administration groups compared to their controls. This was significant in groups, which received LEAD acetate as drinking water for 8 and 12 weeks (P<0.01). Mean cortical volume increased in administration groups in comparison to own controls. This was significant just in 12-weeks group (P<0.01). Mean medullary volume increased in administration groups in comparison to own controls. This was also significant only in 12-week group (P<0.01) . Total volume and cortical volume of KIDNEY in LEAD administration groups showed that total volume in 12 weeks administration group had significant differences in comparison with 4-weeks and 8-weeks groups (P<0.01). There was also showed in 12-weeks administration group a significant difference in comparison with two other administration groups (P<0.01). There was also a significant difference between medullary volumes of 12-weeks administration group with 4-weeks administration group (P<0.01) but when it was compared with 8-weeks administration group, there was not any significant difference between these groups (P<0.05). This study by using a quantitative and precise stereological method showed that LEAD may cause renal injuries in long periods.

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References

A STEREOLOGICAL ANALYSIS OF RENAL GLOMERULI FOLLOWING CHRONIC LEAD INTOXICATION IN RATS DURING A PERIOD OF 12 WEEKS

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APA: Copy

HEIDARI, Z., MAHMOUDZADEH SAGHEB, H.R., RAFIGHDOUST, H., & MOIEN, A.A.. (2003). ANALYSIS OF GROSS ANATOMICAL PARAMETERS OF KIDNEY IN MALE RATS FOLLOWING LEAD POISONING BY USING A STEREOLOGICAL METHOD. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 5(2), 123-134. SID. https://sid.ir/paper/84385/en

Vancouver: Copy

HEIDARI Z., MAHMOUDZADEH SAGHEB H.R., RAFIGHDOUST H., MOIEN A.A.. ANALYSIS OF GROSS ANATOMICAL PARAMETERS OF KIDNEY IN MALE RATS FOLLOWING LEAD POISONING BY USING A STEREOLOGICAL METHOD. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2003;5(2):123-134. Available from: https://sid.ir/paper/84385/en

IEEE: Copy

Z. HEIDARI, H.R. MAHMOUDZADEH SAGHEB, H. RAFIGHDOUST, and A.A. MOIEN, “ANALYSIS OF GROSS ANATOMICAL PARAMETERS OF KIDNEY IN MALE RATS FOLLOWING LEAD POISONING BY USING A STEREOLOGICAL METHOD,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 5, no. 2, pp. 123–134, 2003, [Online]. Available: https://sid.ir/paper/84385/en

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