A STEREOLOGYICAL ANALYSIS OF RENAL GLOMERULI FOLLOWING CHRONIC LEAD INTOXICATION IN RAT DURING A CONTINUOS PERIOD OF 8 WEEKS

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SAGHE H.R.M.; HEIDARI Z.; DEZFOULIAN A.R.; CHITNIS P.; NOORI S.M.H.

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Journal: Zahedan Journal of Research in Medical Sciences Year:2001 | Volume:3 | Issue:2 Page(s): 0-0

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Title

A STEREOLOGYICAL ANALYSIS OF RENAL GLOMERULI FOLLOWING CHRONIC LEAD INTOXICATION IN RAT DURING A CONTINUOS PERIOD OF 8 WEEKS

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Keywords

STEREOLOGYQ3

CAVALIRI"S PRINEIPLEQ4

LEAD ACETATEQ4

GLOMERULQ4

KIDNEYQ2

Abstract

New Page 1 Stereologic methods are used to obtain quantitative infonnation about three dimensional structures from histologic sections. The aim of present study was using new and unbiased stereological techniques to investigate changes in volume and number of glomentli after chronic LEAD ACETATE intoxication. Lead is one of the heavy metals that have adverse effects on renal function. Its effects can involve both renal tubules as well as GLOMERULi. So many studies based on observation and qualitative reports. Some of which, report changes in volume and nwnber of GLOMERULi. Male Wistar rats were randomly divided in four groups (n=9) . During a period of 8 weeks, to treatment groups were given 0.5% and I% lead acetate in drinking water and the control and sham control were given distilled water and 0.4% acetic acid solution respectively. Srereological analysis based on Cavalieries principle was perfomred to determine the reference volume (V reference)the fraction volume of GLOMERULi (V VGlom) and total GLOMERULar volume (V Tglom)Furthermore, for estimating the numerical density (N VGlom) and total number of GLOMERULi (NTGlom), the physical dissector was utilized. Results showed that the number of GLOMERULi in treatment group which recieved 1% lead acetete in drinking water decreased significantly (P<0.05) , but no changes occuned in 0.5% group (P>0.05) . On the other hand glomelular total volume in both 0.5% and I% group increased significantly in comparison to control and sham control groups (P<0.000l). This experiment is in agreement with other qualitative reports by using unbiased stereological methods and showed changes in volume and number of GLOMERULi following LEAD ACETATE intoxication.

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APA: Copy

SAGHE, H.R.M., HEIDARI, Z., DEZFOULIAN, A.R., CHITNIS, P., & NOORI, S.M.H.. (2001). A STEREOLOGYICAL ANALYSIS OF RENAL GLOMERULI FOLLOWING CHRONIC LEAD INTOXICATION IN RAT DURING A CONTINUOS PERIOD OF 8 WEEKS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), 3(2), 0-0. SID. https://sid.ir/paper/361181/en

Vancouver: Copy

SAGHE H.R.M., HEIDARI Z., DEZFOULIAN A.R., CHITNIS P., NOORI S.M.H.. A STEREOLOGYICAL ANALYSIS OF RENAL GLOMERULI FOLLOWING CHRONIC LEAD INTOXICATION IN RAT DURING A CONTINUOS PERIOD OF 8 WEEKS. ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH)[Internet]. 2001;3(2):0-0. Available from: https://sid.ir/paper/361181/en

IEEE: Copy

H.R.M. SAGHE, Z. HEIDARI, A.R. DEZFOULIAN, P. CHITNIS, and S.M.H. NOORI, “A STEREOLOGYICAL ANALYSIS OF RENAL GLOMERULI FOLLOWING CHRONIC LEAD INTOXICATION IN RAT DURING A CONTINUOS PERIOD OF 8 WEEKS,” ZAHEDAN JOURNAL OF RESEARCH IN MEDICAL SCIENCES (TABIB-E-SHARGH), vol. 3, no. 2, pp. 0–0, 2001, [Online]. Available: https://sid.ir/paper/361181/en

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