STUDYING THE 3'UTR (1484INSG) POLYMORPHISM OF PTPLB GENE IN INSULIN-RESISTANT AND TYPE 2 DIABETIC SUBJECTS

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MOUSAPOUR A.; TAGHIKHANI M.; MESHKANI R.; KHATAMI SHOHREH; BAKHTIARI SALAR; HAGHANI K.

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Journal: JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH Year:2007 | Volume:5 | Issue:3 Page(s): 1-13

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Title

STUDYING THE 3'UTR (1484INSG) POLYMORPHISM OF PTPLB GENE IN INSULIN-RESISTANT AND TYPE 2 DIABETIC SUBJECTS

Author(s)

Keywords

INSULIN RESISTANCEQ2

3'UTRQ3

HOMA-IRQ3

POLYMORPHISMQ3

PTP1BQ3

Abstract

Background and Aim: Type 2 diabetes mellitus is a heterogeneous disorder resulting from a combination of genetic and environmental factors which contribute to pathogenesis by influencing beta cell function and tissue insulin sensitivity. Protein tyrosine phosphatase 1B (PTP1B)\ efficiently dephosphorylates the insulin receptor and attenuates insulin signaling. Recently, a l484insG variant of the PTP1B gene was linked to increased risk of the metabolic syndrome in an Italian population, but this was not confirmed in subsequent studies. The purpose of this research was to investigate the association of l484insG POLYMORPHISM of the PTP1B with obesity, INSULIN RESISTANCE, type 2 diabetes and other cardiovascular-related traits in an Iranian population.Materials and Methods: The genotypes of l484insG variant were determined by the PCR-RFLP method in 242 unrelated subjects, including 171 individuals with normal glucose tolerance and normal fasting glucose levels, and 71 type 2 diabetics. INSULIN RESISTANCE was assessed using the homeostasis assessment model.Results: The allelic frequency of the l484insG POLYMORPHISM among type 2 diabetic patients and non-diabetic individuals was 6.3% and 3.8%, respectively (p=0.205). None of the subjects were homozygous for the l484insG allele. Concerning quantitative traits in non-diabetic subjects, carriers of 1484insG allele had significantly higher body mass index (p=0.01), diastolic blood pressure (p=0.012), and HOMA-IR (p= 0.041) levels compared to those carrying the wild-type genotype.In type 2 diabetics, carriers of l484insG allele had only significantly higher HOMA-B (P= 0/04) level compared to the individuals with the wild-type genotype. Conclusion: Our results from a sample of Iranian type 2 diabetes cases and controls provide evidence that the l484insG genotype of the PTP1B gene may be associated with obesity and INSULIN RESISTANCE.

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APA: Copy

MOUSAPOUR, A., TAGHIKHANI, M., MESHKANI, R., KHATAMI, SHOHREH, BAKHTIARI, SALAR, & HAGHANI, K.. (2007). STUDYING THE 3'UTR (1484INSG) POLYMORPHISM OF PTPLB GENE IN INSULIN-RESISTANT AND TYPE 2 DIABETIC SUBJECTS. JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH, 5(3), 1-13. SID. https://sid.ir/paper/84964/en

Vancouver: Copy

MOUSAPOUR A., TAGHIKHANI M., MESHKANI R., KHATAMI SHOHREH, BAKHTIARI SALAR, HAGHANI K.. STUDYING THE 3'UTR (1484INSG) POLYMORPHISM OF PTPLB GENE IN INSULIN-RESISTANT AND TYPE 2 DIABETIC SUBJECTS. JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH[Internet]. 2007;5(3):1-13. Available from: https://sid.ir/paper/84964/en

IEEE: Copy

A. MOUSAPOUR, M. TAGHIKHANI, R. MESHKANI, SHOHREH KHATAMI, SALAR BAKHTIARI, and K. HAGHANI, “STUDYING THE 3'UTR (1484INSG) POLYMORPHISM OF PTPLB GENE IN INSULIN-RESISTANT AND TYPE 2 DIABETIC SUBJECTS,” JOURNAL OF SCHOOL OF PUBLIC HEALTH AND INSTITUTE OF PUBLIC HEALTH RESEARCH, vol. 5, no. 3, pp. 1–13, 2007, [Online]. Available: https://sid.ir/paper/84964/en

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