THE EFFECT OF PRE-OPERATIVE TRANEXAMIC ACID ON BLOODING PREVENTION IN NON-CEMENTE D HIP ARTHROPLASTY

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MOSAFFA FARAMARZ; KAZEMI SEYYED MORTEZA; KAFFASHI MOHAMMAD; EAJAZI ALIREZA; DAFTARI BESHELI LALEH; BIGDELI MOHAMMAD REZA; FARHANG ZANGANEH RAMIN

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Journal: IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY Year:2009 | Volume:7 | Issue:3 (28) Page(s): 114-120

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Title

THE EFFECT OF PRE-OPERATIVE TRANEXAMIC ACID ON BLOODING PREVENTION IN NON-CEMENTE D HIP ARTHROPLASTY

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Keywords

TRANEXAMIC ACIDQ3

ARTHROPLASTYQ3

REPLACEMENTQ2

HIPQ3

HEMORRHAGEQ3

Abstract

Background: Antifibrinolytic drugs are used to minimize the potential risks of bleeding and blood transfusion. Studies showed the effect of TRANEXAMIC ACID on decreasing blood loss in cemented THA. We would like to report its effect on cement less HIP ARTHROPLASTY.Methods: A prospective double blind randomized controlled study was conducted on 64 candidates for cementless THA under epidural anesthesia between 2006 and 2008. The patients were randomly divided into study and control groups.32 patients received TRANEXAMIC ACID (15 mg/kg) and 32 received normal saline immediately before surgery.Results: The comparison of two groups showed less drop in 6 hour (p=0.035) and 24 hour (p=0.043) post-operative hemoglobin levels, less intra-operative bleeding (p=0.024), and less need for allogenic blood transfusion (p=0.017) in the TRANEXAMIC ACID group. Although the mean of 6 and 24 hour hematocrit level was higher and hospital stay was shorter in the TRANEXAMIC ACID group, but the differences were not significant.Conclusion: administration of TRANEXAMIC ACID before cementless THA under epidural anesthesia can reduce intraoperative and post-operative bleeding as well as need for blood transfusion.

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APA: Copy

MOSAFFA, FARAMARZ, KAZEMI, SEYYED MORTEZA, KAFFASHI, MOHAMMAD, EAJAZI, ALIREZA, DAFTARI BESHELI, LALEH, BIGDELI, MOHAMMAD REZA, & FARHANG ZANGANEH, RAMIN. (2009). THE EFFECT OF PRE-OPERATIVE TRANEXAMIC ACID ON BLOODING PREVENTION IN NON-CEMENTE D HIP ARTHROPLASTY. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, 7(3 (28)), 114-120. SID. https://sid.ir/paper/85248/en

Vancouver: Copy

MOSAFFA FARAMARZ, KAZEMI SEYYED MORTEZA, KAFFASHI MOHAMMAD, EAJAZI ALIREZA, DAFTARI BESHELI LALEH, BIGDELI MOHAMMAD REZA, FARHANG ZANGANEH RAMIN. THE EFFECT OF PRE-OPERATIVE TRANEXAMIC ACID ON BLOODING PREVENTION IN NON-CEMENTE D HIP ARTHROPLASTY. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY[Internet]. 2009;7(3 (28)):114-120. Available from: https://sid.ir/paper/85248/en

IEEE: Copy

FARAMARZ MOSAFFA, SEYYED MORTEZA KAZEMI, MOHAMMAD KAFFASHI, ALIREZA EAJAZI, LALEH DAFTARI BESHELI, MOHAMMAD REZA BIGDELI, and RAMIN FARHANG ZANGANEH, “THE EFFECT OF PRE-OPERATIVE TRANEXAMIC ACID ON BLOODING PREVENTION IN NON-CEMENTE D HIP ARTHROPLASTY,” IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, vol. 7, no. 3 (28), pp. 114–120, 2009, [Online]. Available: https://sid.ir/paper/85248/en

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