valuation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats

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TANIDEH NADER; Rostami Nasab Mohammad Amin; Hasanpour Ida; KOOHI HOSSEINABADI OMID; Mojahed maryam; Nabavizadeh Sara Sadat

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Journal: IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY Year:2018 | Volume:16 | Issue:2 (61) Page(s): 185-193

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Title

valuation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats

Author(s)

Keywords

OsteoarthritisQ2

KneeQ2

RadiographyQ1

PathologyQ1

PsidiumQ1

RatsQ1

Abstract

Background: Osteoarthritis (OA) is widespread degenerative joint disease. Although many therapeutic policies exist, no clear preventive remedy exists. Due to various side effects caused by conventional medication; we aim to evaluate the effect of leaf of Psidium guajava essential oil on animal model of OA. Methods: This 8-week animal model study was conducted on 25 male Rats with induced Osteoarthritis with collagenase. The Rats were divided into 5 groups randomly, the first group that serves as negative control group and received intra-articular injections of saline, the second group received olive oil, the third group intra articular(IA)Hyalgan, the fourth group received low dosage (25 λ ) essential oil of Psidium guajava L. leaf, and the last group which received high dosage (50 λ ) essential oil of Psidium guajava L. leaf. All groups received their medication for 4 weeks. After 8 weeks from beginning of study, all of the animals were euthanized with CO2 and samples harvested. All the samples underwent histopathological and radiological evaluation and data were collected and analyzed by Kruskal-Wallis nonparametric test (distribution free) by SPSS version 23. 00. Results: In histopathological findings illustrate a considerable difference between high dose (50λ ) treatment group and the control group. Moreover; in radiographic findings, significant difference was observed between groups in evaluation of distribution in joint space width. (P value =0. 0001) Conclusion: Essential oil of Psidium guajava L. leaf has a considerable positive effect on Osteoarthritis.

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References

Guava fruit extract and its triterpene constituents have osteoanabolic effect: Stimulation of osteoblast differentiation by activation of mitochondrial respiration via the Wnt/beta-catenin signaling

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APA: Copy

TANIDEH, NADER, Rostami Nasab, Mohammad Amin, Hasanpour, Ida, KOOHI HOSSEINABADI, OMID, Mojahed, maryam, & Nabavizadeh, Sara Sadat. (2018). valuation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, 16(2 (61) ), 185-193. SID. https://sid.ir/paper/85509/en

Vancouver: Copy

TANIDEH NADER, Rostami Nasab Mohammad Amin, Hasanpour Ida, KOOHI HOSSEINABADI OMID, Mojahed maryam, Nabavizadeh Sara Sadat. valuation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats. IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY[Internet]. 2018;16(2 (61) ):185-193. Available from: https://sid.ir/paper/85509/en

IEEE: Copy

NADER TANIDEH, Mohammad Amin Rostami Nasab, Ida Hasanpour, OMID KOOHI HOSSEINABADI, maryam Mojahed, and Sara Sadat Nabavizadeh, “valuation of Psidium Guajava L. Leaf Oil Extract Effect on Induced Osteoarthritis in Male Rats,” IRANIAN JOURNAL OF ORTHOPAEDIC SURGERY, vol. 16, no. 2 (61) , pp. 185–193, 2018, [Online]. Available: https://sid.ir/paper/85509/en

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