ANTIGEN-SPECIFIC IL-10 PRODUCING CD4+, 
CD25+ REGULATORY T CELLS IN CHRONICALLY INFECTED HCV PATIENTS

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HASHEMPOOR TAYEBEH; BAMDAD TARAVAT; ARASTEH JAVAD; EMAMZADEH RAHMAN; HAJ SHEIKHOL ESLAMI ARGHAVAN; ASADI REIHANE; MERAT SHAHIN

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Journal: GOVARESH JOURNAL Year:2013 | Volume:18 | Issue:1 (82) Page(s): 7-15

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Title

ANTIGEN-SPECIFIC IL-10 PRODUCING CD4+, CD25+ REGULATORY T CELLS IN CHRONICALLY INFECTED HCV PATIENTS

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Keywords

REGULATORY T CELLSQ2

HEPATITIS C VIRUS INFECTIONQ2

HCV-CORE ANTIGENQ2

Abstract

Background: The mechanism behind the apparent lack of effective antiviral immune response in patients with chronic hepatitis C virus (HCV) infection is poorly understood. Although multiple levels of abnormalities have been identified in innate and adaptive immunity, it is postulated that production of specific cytokines such as IL-10 may contribute to the induction and maintenance of HCV persistence. Production of IL-10 by CD4+, CD25+, IL-10+ REGULATORY T CELLS with regulatory capacity (Tregs) appears to be one of the viral mechanisms that alter the antiviral immune response. As the first report, that attempts to mimic physiological forces that can occur during HCV infection, in this study we evaluate the ability of HCV-CORE ANTIGENs in increasing the frequency of CD4+, CD25+, IL-10+ REGULATORY T CELLS.Materials and Methods: We analyzed peripheral blood mononuclear cells (PBMCs) from chronic HCV-infected patients (n=19) and normal controls (n=6) to determine the effect of the HCV-CORE ANTIGEN in the frequency of HCV-specific IL-10 production.PBMCs of different groups were isolated, cultured and stimulated with core antigen. Then, an in-house triple-stain flow cytometric method was used to investigate the frequency of CD4+, CD25+, IL-10 producing cells.Results: Following incubation of PBMCs with HCV-CORE ANTIGEN, a population of CD4+, CD25+, IL-10+ cells (REGULATORY T CELLS) increased. However we observed no increase in Tregs in the negative controls.Conclusion: The study supports the view that specific CD4+, CD25+, IL-10+T cells may be implicated in host immune tolerance during an HCV infection. It is likely that HCV vaccine candidates avoid epitopes that lead to strong IL-10 production.

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APA: Copy

HASHEMPOOR, TAYEBEH, BAMDAD, TARAVAT, ARASTEH, JAVAD, EMAMZADEH, RAHMAN, HAJ SHEIKHOL ESLAMI, ARGHAVAN, ASADI, REIHANE, & MERAT, SHAHIN. (2013). ANTIGEN-SPECIFIC IL-10 PRODUCING CD4⁺, CD25⁺ REGULATORY T CELLS IN CHRONICALLY INFECTED HCV PATIENTS. GOVARESH JOURNAL, 18(1 (82)), 7-15. SID. https://sid.ir/paper/86180/en

Vancouver: Copy

HASHEMPOOR TAYEBEH, BAMDAD TARAVAT, ARASTEH JAVAD, EMAMZADEH RAHMAN, HAJ SHEIKHOL ESLAMI ARGHAVAN, ASADI REIHANE, MERAT SHAHIN. ANTIGEN-SPECIFIC IL-10 PRODUCING CD4⁺, CD25⁺ REGULATORY T CELLS IN CHRONICALLY INFECTED HCV PATIENTS. GOVARESH JOURNAL[Internet]. 2013;18(1 (82)):7-15. Available from: https://sid.ir/paper/86180/en

IEEE: Copy

TAYEBEH HASHEMPOOR, TARAVAT BAMDAD, JAVAD ARASTEH, RAHMAN EMAMZADEH, ARGHAVAN HAJ SHEIKHOL ESLAMI, REIHANE ASADI, and SHAHIN MERAT, “ANTIGEN-SPECIFIC IL-10 PRODUCING CD4⁺, CD25⁺ REGULATORY T CELLS IN CHRONICALLY INFECTED HCV PATIENTS,” GOVARESH JOURNAL, vol. 18, no. 1 (82), pp. 7–15, 2013, [Online]. Available: https://sid.ir/paper/86180/en

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