Presence of anti-glucose regulated protein78 autoantibodies in the sera of women with recurrent pregnancy loss

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GHARESI FARD B.; KARIMI M.H.; Bidar L.; HASANZADEH M.A.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:26 | Issue:3 Page(s): 169-176

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Title

Presence of anti-glucose regulated protein78 autoantibodies in the sera of women with recurrent pregnancy loss

Author(s)

GHARESI FARD B. | KARIMI M.H. | Bidar L. | HASANZADEH M.A. | Issue Writer Certificate

Keywords

PregnancyQ2

RPLQ1

PlacentaQ1

GRP78Q1

Abstract

Introduction: Recurrent Pregnancy loss (RPL) is defined as three or more miscarriages prior to the 20th week of gestation. This condition occurs in 15-20% of all pregnancies. Glucose-regulated protein 78 (GRP78) is an endoplasmic reticulum (ER) protein that is expressed on the trophoblast cells. The purpose of this study was to evaluate the presence of anti-GRP78 antibodies in the sera of women with RPL. Materials & Methods: This case-control study was conducted 80 women referring to the Infertility Center of Shiraz University of Medical Sciences, Shiraz, Iran, during 2014-2016. The study population was assigned into two groups of case entailing 38 women with unexplained RPL and control including 42 healthy pregnant women with no history of miscarriage and a minimum of two successful pregnancies. The measurement of the anti-GRP78 antibody in the sera of the two groups was performed using the enzyme-linked immunosorbent assay (ELISA). Furthermore, western blot technique was used to assess the expression of GRP78 in Placenta tissue for both groups. Findings: The results of the western blot demonstrated the expression of GRP78 on the trophoblast cells in both groups. Furthermore, anti-GRP78 antibodies were detected in both case and control groups through ELISA. The case group had a lower level of anti-GRP78 antibodies; however, this difference was not statistically significant (P=0. 1). Discussion & Conclusions: The findings of the current study revealed no significant relationship between anti-GRP78 antibody level in RPL patients and healthy pregnant subjects.

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APA: Copy

GHARESI FARD, B., KARIMI, M.H., Bidar, L., & HASANZADEH, M.A.. (2018). Presence of anti-glucose regulated protein78 autoantibodies in the sera of women with recurrent pregnancy loss. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(3 ), 169-176. SID. https://sid.ir/paper/89770/en

Vancouver: Copy

GHARESI FARD B., KARIMI M.H., Bidar L., HASANZADEH M.A.. Presence of anti-glucose regulated protein78 autoantibodies in the sera of women with recurrent pregnancy loss. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(3 ):169-176. Available from: https://sid.ir/paper/89770/en

IEEE: Copy

B. GHARESI FARD, M.H. KARIMI, L. Bidar, and M.A. HASANZADEH, “Presence of anti-glucose regulated protein78 autoantibodies in the sera of women with recurrent pregnancy loss,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 3 , pp. 169–176, 2018, [Online]. Available: https://sid.ir/paper/89770/en

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