Prevalence of CTX-M-3 Type Beta-Lactamase Genes in Various Clinical Specimens of Klebsiella pneumoniaein Sari, Iran

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AHANJAN M.; ABDOLLAHI M.; HASHEMI B.; NAZAR E.; MORSAL JAHAN Z.

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Title

Prevalence of CTX-M-3 Type Beta-Lactamase Genes in Various Clinical Specimens of Klebsiella pneumoniaein Sari, Iran

Author(s)

Keywords

Spectrum ßQ1

lactamasesQ1

Klebsiella pneumoniaeQ1

CTXQ1

MQ1

3Q1

Abstract

Introduction: The wideuse of beta-lactam antibacterial agents in the treatment of bacterial infections has increased bacterial resistance. Nowadays, one of the problems in the treatment of nosocomial infections is enzymes resistance to broad spectrum betalactamases among clinical isolates, especially Klebsiella pneumoniae. Over the past decade, CTX-M type enzymes have been recognized asthe most common type of broad-spectrum beta-lactamase in Europe, Canada, and Asia. The aim of this study was to evaluate the prevalence of broad-spectrum beta-lactamaseproducingKlebsiella pneumoniae bacteria and to identify the CTX-M-3 gene by molecular method. Materials & Methods: Over a 9-month period, 130 Klebsiella pneumoniaewere isolated from different clinical specimens (urine, blood, ulcers) of infectious patients in Imam Khomeini Hospital, Sari, Iran. Their susceptibility to nine antibiotics used for gram-negative bacteria was measured by disk diffusion agar method. The extended-spectrum beta-lactamases (ESBLs) producing isolates were identified using a hybrid disc method. Moreover, strains producing CTX-M-3 enzyme were detectedby polymerase chain reactionmethod. Findings: The 48 (36. 8%) isolates of Klebsiella pneumoniaewere the producer of ESBLs. Moreover, 22 (16. 9%) of these cases contained the CTX-M-3 gene. Discussion & Conclusions: The obtained results of the currentstudy showed that the prevalence of ESBL producing strains resistant to quinolones is higher in Iran, compared to the developed countries.

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APA: Copy

AHANJAN, M., ABDOLLAHI, M., HASHEMI, B., NAZAR, E., & MORSAL JAHAN, Z.. (2019). Prevalence of CTX-M-3 Type Beta-Lactamase Genes in Various Clinical Specimens of Klebsiella pneumoniaein Sari, Iran. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(5 ), 96-102. SID. https://sid.ir/paper/89807/en

Vancouver: Copy

AHANJAN M., ABDOLLAHI M., HASHEMI B., NAZAR E., MORSAL JAHAN Z.. Prevalence of CTX-M-3 Type Beta-Lactamase Genes in Various Clinical Specimens of Klebsiella pneumoniaein Sari, Iran. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(5 ):96-102. Available from: https://sid.ir/paper/89807/en

IEEE: Copy

M. AHANJAN, M. ABDOLLAHI, B. HASHEMI, E. NAZAR, and Z. MORSAL JAHAN, “Prevalence of CTX-M-3 Type Beta-Lactamase Genes in Various Clinical Specimens of Klebsiella pneumoniaein Sari, Iran,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 5 , pp. 96–102, 2019, [Online]. Available: https://sid.ir/paper/89807/en

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