TOPICAL EFFECTS OF ALOEVERA AND PROPOLIS ON OPEN WOUND HEALING IN MALE RATS

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GHEIBI N.; SOFIABADI M.; ASGHARI S.; AHMADI E.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:23 | Issue:4 (SUPPLEMENT) Page(s): 32-40

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Title

TOPICAL EFFECTS OF ALOEVERA AND PROPOLIS ON OPEN WOUND HEALING IN MALE RATS

Author(s)

GHEIBI N. | SOFIABADI M. | ASGHARI S. | AHMADI E. | Issue Writer Certificate

Keywords

WOUND HEALINGQ2

ALOEVERAQ2

PROPOLISQ2

RATQ1

Abstract

Introduction: Traditionally, the natural ingredients have been used for faster healing of wounds. In this study, the effects of topical application of PROPOLIS and aloe vera were studied on the healing of open skin wounds in male RATs.Materials & methods: 32 male Wistar RATs (300 - 350 g) were randomly divided into control and 3 experimental groups. After anesthesia, under sterile conditions round full-thickness wound with a diameter of 2.5 cm were created above the thigh of animals. In experimental groups, treatment of wound was performed with usage of ointment containing approximately 1gram of PROPOLIS or aloe vera or both of them, two times per day and continued for 20 days. During this period, the RATe of WOUND HEALING was assessed by measuring the levels of wound in all groups. Also at the last day, under deep anesthesia, 1 mL of urine samples were taken from the bladder of all animals and its hydroxyproline concentration were measured. Data were analyzed using SPSS software with ANOVA and Dunnett test.Findings: WOUND HEALING percentage showed no significant difference between control and experimental groups on 2 to 9 days, but in the 10 to 20 days interval, the treatment groups showed significant differences compared to control (P<0.01).Discussion & Conclusion: The topical use of aloe vera or PROPOLIS accelerates healing of full thickness skin wounds and their combination is more effective.

Cites

EFFECT OF ORAL ADMINISTRATION OF ETHANOLIC EXTRACTS OF PROPOLIS ON PASSIVE AVOIDANCE LEARNING AND MEMORY IN ADULT MALE MICE

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APA: Copy

GHEIBI, N., SOFIABADI, M., ASGHARI, S., & AHMADI, E.. (2015). TOPICAL EFFECTS OF ALOEVERA AND PROPOLIS ON OPEN WOUND HEALING IN MALE RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 23(4 (SUPPLEMENT)), 32-40. SID. https://sid.ir/paper/89888/en

Vancouver: Copy

GHEIBI N., SOFIABADI M., ASGHARI S., AHMADI E.. TOPICAL EFFECTS OF ALOEVERA AND PROPOLIS ON OPEN WOUND HEALING IN MALE RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;23(4 (SUPPLEMENT)):32-40. Available from: https://sid.ir/paper/89888/en

IEEE: Copy

N. GHEIBI, M. SOFIABADI, S. ASGHARI, and E. AHMADI, “TOPICAL EFFECTS OF ALOEVERA AND PROPOLIS ON OPEN WOUND HEALING IN MALE RATS,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 4 (SUPPLEMENT), pp. 32–40, 2015, [Online]. Available: https://sid.ir/paper/89888/en

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