ASSOCIATION OF PINK1GENE POLYMORPHISM ALA340THR WITH TYPE 2 DIABETES IN SISTAN AND BALUCHISTAN PROVINCE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

GHAYORI B.; RASHKI A.; MOTALEB G.; DAHMARDEI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2015 | Volume:23 | Issue:1 Page(s): 127-133

Download Full-Text

Persian Verion

View:

681

Download:

Cites:

Information Journal Paper

Title

ASSOCIATION OF PINK1GENE POLYMORPHISM ALA340THR WITH TYPE 2 DIABETES IN SISTAN AND BALUCHISTAN PROVINCE

Author(s)

GHAYORI B. | RASHKI A. | MOTALEB G. | DAHMARDEI M. | Issue Writer Certificate

Keywords

TYPE 2 DIABETES MELLITUSQ1

RFLP-PCRQ1

POLYMORPHISMQ1

PINK1Q2

Abstract

Introduction: One of the genes that have been recently approvd to be associated with diabetes mellitus type 2 is PINK1. This gene encodes a serine/threonine protein kinase that located in mitochondria. It is thought that it protects cells from stress-induced mitochondrial dysfunction. The aim of the present study was to investigate the association between PINK1 gene POLYMORPHISM Ala340Thr with Type 2 diabetes.Materials & Methods: In the present case-control study, one hundred patients with TYPE 2 DIABETES MELLITUS and 100 non-diabetic healthy people were selected randomly from the studied population. The PINK1 gene POLYMORPHISM (Ala340Thr) was determined using polymerase chain reaction and restriction fragment length POLYMORPHISM genotyping assays (PCR-Findings: The frequency of G and A alleles in patient and control groups was 93.5%, 95% and 6.5%, 5% respectively. In this study allele frequency didn´t show any significant difference between patient and control groups. The frequency of GG and GA for PINK1 gene was 87% and 13% in patient group, and 90% and10% in control group respectively Discussion & Conclusion: According to the obtained results in this study, there isn´t any significant correlation between Ala340Thr variant of PINK1 with Type 2 diabetes. The Ala340Thr variant could not present as a risk factor for type 2 diabetes.

Cites

No record.

References

No record.

Cite

APA: Copy

GHAYORI, B., RASHKI, A., MOTALEB, G., & DAHMARDEI, M.. (2015). ASSOCIATION OF PINK1GENE POLYMORPHISM ALA340THR WITH TYPE 2 DIABETES IN SISTAN AND BALUCHISTAN PROVINCE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 23(1), 127-133. SID. https://sid.ir/paper/89921/en

Vancouver: Copy

GHAYORI B., RASHKI A., MOTALEB G., DAHMARDEI M.. ASSOCIATION OF PINK1GENE POLYMORPHISM ALA340THR WITH TYPE 2 DIABETES IN SISTAN AND BALUCHISTAN PROVINCE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;23(1):127-133. Available from: https://sid.ir/paper/89921/en

IEEE: Copy

B. GHAYORI, A. RASHKI, G. MOTALEB, and M. DAHMARDEI, “ASSOCIATION OF PINK1GENE POLYMORPHISM ALA340THR WITH TYPE 2 DIABETES IN SISTAN AND BALUCHISTAN PROVINCE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 23, no. 1, pp. 127–133, 2015, [Online]. Available: https://sid.ir/paper/89921/en

Related Journal Papers