EFFECTIVENESS OF EXOGEN TESTOSTERONE AND FINASTERID ON MORPHINE ANALGESIA IN MALE MICES USING FORMALIN TEST

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NASRI S.; YOUSOFVAND N.; KHANI S.

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Journal: Journal of Ilam University of Medical Sciences Year:2011 | Volume:19 | Issue:2 Page(s): 38-47

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Title

EFFECTIVENESS OF EXOGEN TESTOSTERONE AND FINASTERID ON MORPHINE ANALGESIA IN MALE MICES USING FORMALIN TEST

Author(s)

NASRI S. | YOUSOFVAND N. | KHANI S. | Issue Writer Certificate

Keywords

ANALGESIAQ2

FINASTERIDEQ2

MORPHINEQ2

TESTOSTERONEQ1

MALE MICEQ2

Abstract

Introduction: Intensity of pain in both the male and female sexes is different. This difference suggests that sexual hormones may affect on pain system. One such variant is the possible effect of nongonadal hormones on the pain. The aim of the current study was to evaluate the effect iveness of exogenous TESTOSTERONE and FINASTERIDE, antiandrogen drug, on MORPHINE ANALGESIA in MALE MICE using formalin test.Materials & Methods: In this study, MALE MICE were divided into 6 groups (N=7);saline TESTOSTERONE, seasame seed oil, MORPHINE or antiandrogen drug FINASTERIDE. Formalin test was performed in all the mice and data were analyzed by oneway ANOVA.Findings: Reduced ANALGESIA due to using MORPHINE in the group which received TESTOSTERONE (or seasame seed oil) and MORPHINE was found out to be less compared to that of the group that received MORPHINE, (P<0.05,P<0.01). ANALGESIA in the group which received FINASTERIDE and MORPHINE showed an increase compared to the group that only received MORPHINE,(P<0.05).Discussion & Conclusion: It can be concluded that either exogenous TESTOSTERONE and endogen TESTOSTERONE can reduced ANALGESIA due to MORPHINE. On the other hand, antiandrogen drug (finasteride) increases ANALGESIA of MORPHINE that may be due to elimination of endogen TESTOSTERONE that results in elimination of adverse effects of TESTOSTERONE with MORPHINE or may be some sort of antiANALGESIA effects of FINASTERIDE.

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APA: Copy

NASRI, S., YOUSOFVAND, N., & KHANI, S.. (2011). EFFECTIVENESS OF EXOGEN TESTOSTERONE AND FINASTERID ON MORPHINE ANALGESIA IN MALE MICES USING FORMALIN TEST. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 19(2), 38-47. SID. https://sid.ir/paper/90035/en

Vancouver: Copy

NASRI S., YOUSOFVAND N., KHANI S.. EFFECTIVENESS OF EXOGEN TESTOSTERONE AND FINASTERID ON MORPHINE ANALGESIA IN MALE MICES USING FORMALIN TEST. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;19(2):38-47. Available from: https://sid.ir/paper/90035/en

IEEE: Copy

S. NASRI, N. YOUSOFVAND, and S. KHANI, “EFFECTIVENESS OF EXOGEN TESTOSTERONE AND FINASTERID ON MORPHINE ANALGESIA IN MALE MICES USING FORMALIN TEST,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 2, pp. 38–47, 2011, [Online]. Available: https://sid.ir/paper/90035/en

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