EVALUATION OF CURCUMIN OINTMENT EFFECTS ON DINITROCHLOROBENZENEINDUCED CONTACT DERMATITIS IN MOUSE

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HASHEMI F.; KAZEMI DARABADI S.; AKBARI H.; KHORDADMEHR M.

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Journal: Journal of Ilam University of Medical Sciences Year:2017 | Volume:25 | Issue:1 Page(s): 195-210

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Title

EVALUATION OF CURCUMIN OINTMENT EFFECTS ON DINITROCHLOROBENZENEINDUCED CONTACT DERMATITIS IN MOUSE

Author(s)

HASHEMI F. | KAZEMI DARABADI S. | AKBARI H. | KHORDADMEHR M. | Issue Writer Certificate

Keywords

CONTACT DERMATITISQ1

DINITROCHLOROBENZENEQ1

CURCUMINQ1

ANTIINFLAMMATIONQ1

MOUSEQ1

Abstract

Introduction: One of the post-surgicalcomplications is CONTACT DERMATITIS caused by several factors such as scrub solution, suture materials, bandages and even surgical gloves. Conventional treatment forthis problem is the use of corticosteroidsthat may cause undesirable side-effects. CURCUMIN is the active component of turmeric that have known antiinflammatory effects. Therefore, its effectson experimentally induced contactdermatitis were investigated in this study.Materials & Methods: Twenty maleBALB/c mice were used in this study. Themice were equally divided into four groups. The negative control (NC), positive control (PC), and treatment (T) groups were sensitized by DINITROCHLOROBENZENE paintingon dorsum of the mice, followed by contactdermatitis induction on their ear. CURCUMINand Betamethasone topical ointments were applied to the ear of the T and PC groups for a week, respectively. CONTACT DERMATITISleft untreated in the NC and sham (S)groups. Ear thickness was measured duringthe study. After completing the course oftreatment, the mice were euthanized and earspecimens were fixed, sectioned and stained with hematoxylin and eosin.Findings: Macroscopic evaluations revealedthat CONTACT DERMATITIS was induced in all of the NC, PC, and T groups successfully. Earthickness differences in day 22 and 30 were significant (p<0.05). Histopathologic data analysis showed edema, inflammation, and epidermal thickness were significantly different in S group compared with NC. Inflammation was significantly different between S and PC groups, but edema and epidermal thickness have not such difference. Comparison of the T group withthe S group showed that difference between edema is not significant, but in flammationand epidermal thickness are significantly different. Differences between T and NC groups showed the same results.Discussion & Conclusion: Based on the results, we can conclude that to picalapplication of CURCUMIN ointment to the mice suffering from CONTACT DERMATITIS mayreduce inflammation, edema, and epidermal thickening, which is comparable to the effects of corticosteroid medications.

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APA: Copy

HASHEMI, F., KAZEMI DARABADI, S., AKBARI, H., & KHORDADMEHR, M.. (2017). EVALUATION OF CURCUMIN OINTMENT EFFECTS ON DINITROCHLOROBENZENEINDUCED CONTACT DERMATITIS IN MOUSE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 25(1), 195-210. SID. https://sid.ir/paper/90090/en

Vancouver: Copy

HASHEMI F., KAZEMI DARABADI S., AKBARI H., KHORDADMEHR M.. EVALUATION OF CURCUMIN OINTMENT EFFECTS ON DINITROCHLOROBENZENEINDUCED CONTACT DERMATITIS IN MOUSE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;25(1):195-210. Available from: https://sid.ir/paper/90090/en

IEEE: Copy

F. HASHEMI, S. KAZEMI DARABADI, H. AKBARI, and M. KHORDADMEHR, “EVALUATION OF CURCUMIN OINTMENT EFFECTS ON DINITROCHLOROBENZENEINDUCED CONTACT DERMATITIS IN MOUSE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 25, no. 1, pp. 195–210, 2017, [Online]. Available: https://sid.ir/paper/90090/en

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