THE INFLAMMATORY ROLE OF MYELOPEROXIDASE AND ITS INCREASED LEVEL IN PATIENTS WITH CORONARY ARTERY DISEASE

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POURNOSRAT K.; SOLEIMANNEJAD K.; YAGHMAEI P.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:22 | Issue:5 Page(s): 168-178

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Title

THE INFLAMMATORY ROLE OF MYELOPEROXIDASE AND ITS INCREASED LEVEL IN PATIENTS WITH CORONARY ARTERY DISEASE

Author(s)

POURNOSRAT K. | SOLEIMANNEJAD K. | YAGHMAEI P. | Issue Writer Certificate

Keywords

MYELOPEROXIDAESQ2

CADQ2

STABLEQ2

UNSTABLEQ2

Abstract

Introduction: Myeloperoxidase (MPO) has an essential role in the promotion of ather-osclerosis andcoronary artery disease (CA-D). Therefore, this study explored the plasma level of this enzyme in relation to other traditional cardiovascular risk factors in patients with STABLE and UNSTABLE CAD as compared to control subjects.Materials & Methods: In this study, 30patients with STABLE CAD, 30patients with UNSTABLE CAD and 30 control subjects were selected based on angiography procedure. Plasma MPO was measured using an immunoassay method. High sensitivity C-reactive protein (hsCRP) level was determined by a latex-enhanced immunot-urb-id-imetric method. Plasma lipid and lip-op-rotein profiles (LDL-cholesterol, HDL-cholesterol, total cholesterol and triglycerides) were also determined by enzymatic methods. Other cardiovascular risk factors were also assigned through medical history and questionnaire.Findings: MPO and hsCRP levels were significantly higher in UNSTABLE CAD patients than STABLE CAD patients. Also, the amounts of these two biomarkers were higher in STABLE CAD patients than control subjects (P<0.01). In patients, MPO level had a significant relationship with hsCRP and the presence of CAD (P<0.01).Discussion & Conclusion: Elevated level of MPO was a positive independent predictor for the presence of CAD and its plasma levels can differentiate between UNSTABLE C-AD patients, STABLE CAD patients and control subjects and may have a diagnostic value.

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APA: Copy

POURNOSRAT, K., SOLEIMANNEJAD, K., & YAGHMAEI, P.. (2014). THE INFLAMMATORY ROLE OF MYELOPEROXIDASE AND ITS INCREASED LEVEL IN PATIENTS WITH CORONARY ARTERY DISEASE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 22(5), 168-178. SID. https://sid.ir/paper/90104/en

Vancouver: Copy

POURNOSRAT K., SOLEIMANNEJAD K., YAGHMAEI P.. THE INFLAMMATORY ROLE OF MYELOPEROXIDASE AND ITS INCREASED LEVEL IN PATIENTS WITH CORONARY ARTERY DISEASE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(5):168-178. Available from: https://sid.ir/paper/90104/en

IEEE: Copy

K. POURNOSRAT, K. SOLEIMANNEJAD, and P. YAGHMAEI, “THE INFLAMMATORY ROLE OF MYELOPEROXIDASE AND ITS INCREASED LEVEL IN PATIENTS WITH CORONARY ARTERY DISEASE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 5, pp. 168–178, 2014, [Online]. Available: https://sid.ir/paper/90104/en

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