THE EFFICACITY OF ABELMOSCHUS ESCULENTUS FRUIT ON INSULIN CONTROL IN DIABETIC MALE WISTAR RATS

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MASOUDI S.; ORYAN S.; HOSEINI F.; FALLAHI R.

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Journal: Journal of Ilam University of Medical Sciences Year:2016 | Volume:24 | Issue:1 Page(s): 133-143

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Title

THE EFFICACITY OF ABELMOSCHUS ESCULENTUS FRUIT ON INSULIN CONTROL IN DIABETIC MALE WISTAR RATS

Author(s)

MASOUDI S. | ORYAN S. | HOSEINI F. | FALLAHI R. | Issue Writer Certificate

Keywords

INSULINQ2

ABELMOSCHUS ESCULENTUSQ1

DIABETESQ1

RATQ2

Abstract

Introduction: DIABETES mellitus is a metabolic disorder characterized by hyperglycemia due to defective secretion or activity of INSULIN or both. This study was done to investigate the effects of oral administration of ABELMOSCHUS ESCULENTUS(AE) fruits on blood levels of glucose andINSULIN in diabetic RATs.Matherials & methods: 25 animals were grouped into five: normal control (NC), diabetic control (DC), and 3 diabetic groupsthat received 200, 400 and 600 mg/kg/body weight of AE powder in their standard food. NC and DC groups fed with standard food. DIABETES mellitus was induced by single doze intraperitoneal injection of streptozotocin 60 mg/kg/body weight indiabetic groups. The period of experimentwas 3 weeks after confirming DIABETESinduction and each group received it sparticular diet at this time. Blood sampleswere collected at the end of experiments. Obtained data were analyzed with excel and SPSS software.Findings: The results indicated that glucoselevel in DC group not only shows significant growth compared with NC group but also show sign ificant reductionand reaches to normal level in treateddiabetic group compared with DC group.INSULIN level in DC group shows sign ificantreduction compared with NC group but despite of sign ificant increase of INSULIN level in each treated diabetic groups, only 200 mg/kg bw treated group showed normal level of INSULIN compared with DC group.Discussion & Conclusions: Despite of notgetting to normal level of INSULIN in upperdose of treated groups, AE fruit couldget glucose to normal levels in each treatedgroups.

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APA: Copy

MASOUDI, S., ORYAN, S., HOSEINI, F., & FALLAHI, R.. (2016). THE EFFICACITY OF ABELMOSCHUS ESCULENTUS FRUIT ON INSULIN CONTROL IN DIABETIC MALE WISTAR RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 24(1), 133-143. SID. https://sid.ir/paper/90140/en

Vancouver: Copy

MASOUDI S., ORYAN S., HOSEINI F., FALLAHI R.. THE EFFICACITY OF ABELMOSCHUS ESCULENTUS FRUIT ON INSULIN CONTROL IN DIABETIC MALE WISTAR RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2016;24(1):133-143. Available from: https://sid.ir/paper/90140/en

IEEE: Copy

S. MASOUDI, S. ORYAN, F. HOSEINI, and R. FALLAHI, “THE EFFICACITY OF ABELMOSCHUS ESCULENTUS FRUIT ON INSULIN CONTROL IN DIABETIC MALE WISTAR RATS,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 1, pp. 133–143, 2016, [Online]. Available: https://sid.ir/paper/90140/en

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