The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats

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Mohammad zamani T.; MOVAHEDI A.; ARABAMERI E.

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Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2019 | Volume:26 | Issue:6 Page(s): 143-155

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Title

The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats

Author(s)

Mohammad zamani T. | MOVAHEDI A. | ARABAMERI E. | Issue Writer Certificate

Keywords

Compulsory sportsQ1

Prenatal stressQ1

Substantia nigra tissueQ1

Parkinson’s diseaseQ1

Abstract

Introduction: Prenatal stress causes brain alteration and prolongs effects on structure and function. Parkinson's is a progressive neurodegenerative disease And one of the factors motive Parkinson's is the Prenatal stress. Exercising activity is a good way to prevent the disease. The aim of this study was to investigate the effect of mandatory exercise on Substantia nigra tissue in Perinatal Parkinson's rats. Materials & Methods: A Laboratory research method was used. 48 Wistar male rats, half of them under Prenatal stress And followed up on Compulsory sports activities. Were divided into 8 groups of 6, with stress (control, sham, Parkinson, Parkinson + compulsory exercise) and without stress (control, sham, Parkinson, Parkinson + compulsory exercise). the animals received Stereotaxic Surgery after 8 weeks, Three weeks later, Parkinson's symptoms were evaluated using Apo morphine rotation test and Wire grasping. The number of substantia nigra neurons in the brain is counted using a microscope; Data were analyzed using One-Way ANOVA and Tukey's Post Test. Ethics code: IR. IAU. SRB. REC. 1396 Findings: In groups with and without stress, the number of substantia nigra neurons Compulsory sports group was different from that of the control group and this difference was statistically significant (P=0. 0000). The average number of substantia nigra neurons Compulsory sports group in both groups with and without stress difference was low, but statistically significant (P=0. 014). Discussion & conclusions: The results refer to the effects of compulsive exercise on the better protection of Substantia nigra neurons and suggests that exercise can be effective as a beneficial factor in reducing the degeneration of dopaminergic neurons in Parkinson's disease. Prenatal stress also reduces the beneficial effects of exercise.

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References

WEffectiveness of physical activity on patients with depression and Parkinson disease: A systematic review

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APA: Copy

Mohammad zamani, T., MOVAHEDI, A., & ARABAMERI, E.. (2019). The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(6 ), 143-155. SID. https://sid.ir/paper/90180/en

Vancouver: Copy

Mohammad zamani T., MOVAHEDI A., ARABAMERI E.. The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;26(6 ):143-155. Available from: https://sid.ir/paper/90180/en

IEEE: Copy

T. Mohammad zamani, A. MOVAHEDI, and E. ARABAMERI, “The Effect of Compulsory Sports Activities on Substantia Nigra Tissue and Behavioral Tests Induction Parkinsons Model with 6-Hydroxydopamine in Prenatal Stress Rats,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 6 , pp. 143–155, 2019, [Online]. Available: https://sid.ir/paper/90180/en

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