FREQUENCY OF OMPK35 AND OMPK36 IN STRAINS OF KLEBSIELLA PNEUMONIA PRODUCING EXTENDED SPECTRUM BETA-LACTAMASES AND NON-EXTENDED SPECTRUM BETA-LACTAMASES

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SHAKIB P.; SADEGHIFARD N.; ZOLFAGHARY M.R.; GAFOURYAN S.; MALEKI A.; MOHEBI R.; RANJBAR R.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2011 | Volume:19 | Issue:3 Page(s): 13-20

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Title

FREQUENCY OF OMPK35 AND OMPK36 IN STRAINS OF KLEBSIELLA PNEUMONIA PRODUCING EXTENDED SPECTRUM BETA-LACTAMASES AND NON-EXTENDED SPECTRUM BETA-LACTAMASES

Author(s)

Keywords

ESBLS (EXTENDED SPECTRUM BETA-LACTAMASES)Q2

OMPK35Q2

OMPK36Q2

Abstract

Introduction: Klebsiella pneumonia is a major nosocomial pathogen causing pneumonia, urinary tract infections, and bacteremia, particularly in immunecompromised patients. The aim of our study was expression of OMPK36 and OMPK35 in ESBLs production and non-ESBLs K.pneumoniae.Materials & Methods: Clinical isolates of K.pneumoniae were identified. ESBLs were assayed by Phenotypic (screening and confirming) and genotypic (PCR) methods. OMPK35 and OMPK36 were tested by polymerase chain reaction and SDS- PAGE.Findings: Our findings showed that 42.3% of K.pneumoniae were ESBLs positive. Twenty-two K.pneumoniae producing ESBLS and Twenty-two non-ESBLs K.pneumoniae were selected for porines detection. We found out that 54.54% and 72.72% of K.pneumoniae producing ESBLS were positive for OMPK35 and OMPK36 respectively, while our findings in non-ESBLs K.pneumoniae showed that 95.94% and 100% of isolates were positive for OMPK35 and OMPK36, respectively.Discussion & Conclusion: Many of clinical isolates of non- ESBL K. pneumoniae had expressed both OMPK35 and OMPK36 porins, while our results in ESBLs positive K.pneumoniae had only showed expression of OMPK36. A few of non-ESBLs and ESBLs K.pneumoniae were found as negative for both OMPK35 and OMPK36. Our findings released that lack of porins in K.pneumoniae are defined as an antibiotic- resistant mechanism in many isolates.

Cites

A COMPARISON BETWEEN THE EFFECTS OF ANTIBIOTICS AND CELL FREE SUPERNATANT OF LACTOBACILLUS SPP. ON GROWTH OF ESBL POSITIVE K. PNEUMONIA

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APA: Copy

SHAKIB, P., SADEGHIFARD, N., ZOLFAGHARY, M.R., GAFOURYAN, S., MALEKI, A., MOHEBI, R., & RANJBAR, R.. (2011). FREQUENCY OF OMPK35 AND OMPK36 IN STRAINS OF KLEBSIELLA PNEUMONIA PRODUCING EXTENDED SPECTRUM BETA-LACTAMASES AND NON-EXTENDED SPECTRUM BETA-LACTAMASES. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 19(3), 13-20. SID. https://sid.ir/paper/90218/en

Vancouver: Copy

SHAKIB P., SADEGHIFARD N., ZOLFAGHARY M.R., GAFOURYAN S., MALEKI A., MOHEBI R., RANJBAR R.. FREQUENCY OF OMPK35 AND OMPK36 IN STRAINS OF KLEBSIELLA PNEUMONIA PRODUCING EXTENDED SPECTRUM BETA-LACTAMASES AND NON-EXTENDED SPECTRUM BETA-LACTAMASES. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2011;19(3):13-20. Available from: https://sid.ir/paper/90218/en

IEEE: Copy

P. SHAKIB, N. SADEGHIFARD, M.R. ZOLFAGHARY, S. GAFOURYAN, A. MALEKI, R. MOHEBI, and R. RANJBAR, “FREQUENCY OF OMPK35 AND OMPK36 IN STRAINS OF KLEBSIELLA PNEUMONIA PRODUCING EXTENDED SPECTRUM BETA-LACTAMASES AND NON-EXTENDED SPECTRUM BETA-LACTAMASES,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 19, no. 3, pp. 13–20, 2011, [Online]. Available: https://sid.ir/paper/90218/en

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