MICRORNAS IN CANCER THERAPY

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MOTAMED N.; JAHANAFROOZ Z.

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Journal Paper

Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:22 | Issue:SUPPLEMENT Page(s): 91-101

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Information Journal Paper

Title

MICRORNAS IN CANCER THERAPY

Author(s)

MOTAMED N. | JAHANAFROOZ Z. | Issue Writer Certificate

Keywords

MICRORNAQ2

CANCERQ2

ONCOGENEQ2

TUMOR SUPPRESSORQ2

TARGET GENEQ2

Abstract

Despite advances in diagnosis and therapy, CANCER is still the leading cause of death worldwide. Beside the genetic and environmental factors, epigenetic factors also contribute to the etiology of CANCER. More recently, a new class of small non-coding RNAs called MICRORNAs (miRs or miRNAs) has been linked to several human diseases, including CANCER. MICRORNAs are involved in eukaryotic gene regulation, either by translational inhibition or exonucleolytic mRNA decay, targeted through imperfect complementarity between the MICRORNA and the 3′- un-translated region (3′-UTR) of the mRNA. Considering the potential of micro- RNAs in targeting many of human mRNA, these classes of 19-25 oligonucleotides are involved in almost every biological process, including cell cycle regulation, cell growth, apoptosis, cell differentiation and stress response. Growing evidence suggests that MICRORNAs have a vital role in CANCER biology and recent studies have confirmed the oncogenic or tumour suppression role of MICRORNA in CANCER cells. It have been shown that MICRORNA expression can itself be regulated both through ONCOGENEs or tumour suppressors. There is a probability that MICRORNA expression can be regulated both in in vitro and in vivo by developing synthetic pre-MICRORNA molecules or antiMICRORNA antisense oligodeoxyribonucleotides which show a promising prospect of a possible use in curing CANCER.

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APA: Copy

MOTAMED, N., & JAHANAFROOZ, Z.. (2014). MICRORNAS IN CANCER THERAPY. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 22(SUPPLEMENT), 91-101. SID. https://sid.ir/paper/90242/en

Vancouver: Copy

MOTAMED N., JAHANAFROOZ Z.. MICRORNAS IN CANCER THERAPY. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(SUPPLEMENT):91-101. Available from: https://sid.ir/paper/90242/en

IEEE: Copy

N. MOTAMED, and Z. JAHANAFROOZ, “MICRORNAS IN CANCER THERAPY,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. SUPPLEMENT, pp. 91–101, 2014, [Online]. Available: https://sid.ir/paper/90242/en

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