THE EFFECT OF BERBERINE CHLORIDE ON HIPPOCAMPUS OXIDATIVE STRESS OF STREPTOZOTOCIN-DIABETIC RATS

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KALALIANMOGHADAM H.; BALOCHNEJADMOJARAD T.; RAOGHANI M.; KHAKSARI M.; PIRASTEH N.; MOJGAN F.; AHOOEE M.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2014 | Volume:22 | Issue:SUPPLEMENT Page(s): 123-131

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Title

THE EFFECT OF BERBERINE CHLORIDE ON HIPPOCAMPUS OXIDATIVE STRESS OF STREPTOZOTOCIN-DIABETIC RATS

Author(s)

Keywords

DIABETES MELLITUSQ1

BERBERINEQ2

OXIDATIVE STRESSQ1

COGNITIVE DYSFUNCTIONQ2

RATQ1

Abstract

Introduction: DIABETES MELLITUS increases the risk of central nervous system (CNS) disorders such as stroke, seizures, dementia, and cognitive impairment. BERBERINE, a natural isoquinolne alkaloid, is reported to exhibit beneficial effect in various neurodegenerative and neuropsychiatric disorders. Through Enzymatic and non-enzymatic processes, hyperglycemia induces glucose spontaneous oxidation and leads to OXIDATIVE STRESS by stimulating the production of active oxygen and nitrogen. Also, overproduction of ROS can cause DNA and proteins damage and affect the function of receptors, enzymes, transport proteins, and inactive antioxidant defense system enzymes or enzymes involved in the repair.Material & Methods: In this study, the male wistar RATs (n=90) were randomly allocated into five groups: control, control BERBERINE- treated (100 mg/kg), diabetic, BERBERINE- treated diabetic (50, 100 mg/kg) groups. Diabetes was induced intraperinoneally STZ administration at the dose of 60mg/kg. BERBERINE was orally administered at doses of 50 and 100 mg/kg/day one week after STZ injection for a period of 8 weeks. Blood samples were taken from the tail vein 2, 4, 6, 8 weeks after STZ injection to measure blood glucose levels. Lipid peroxidation, nitrite levels and superoxide dismutase activity were evaluated as biomarkers of OXIDATIVE STRESS. Data were analyzed using Prism-5, one-way ANOVA and Tukey tests. Findings: Eight weeks after diabetes induction we observed an increased lipid peroxidation, decreased superoxide dismutase activity, and elevated nitrite levels in the hippocampus of STZ-diabetic RATs than the control brains. In contrast, chronic treatment with BERBERINE (50 and 100 mg/kg, p.o., once daily) lowered hyperglycemia, OXIDATIVE STRESS, and prevented the up regulation of GFAP in the brain of diabetic RATs.Discussion & Conclusion: The present study demonstrated that treatment with BERBERINE resulted in an obvious reduction of OXIDATIVE STRESS in hippocampus of STZ - induced diabetic RATs.

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APA: Copy

KALALIANMOGHADAM, H., BALOCHNEJADMOJARAD, T., RAOGHANI, M., KHAKSARI, M., PIRASTEH, N., MOJGAN, F., & AHOOEE, M.. (2014). THE EFFECT OF BERBERINE CHLORIDE ON HIPPOCAMPUS OXIDATIVE STRESS OF STREPTOZOTOCIN-DIABETIC RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 22(SUPPLEMENT), 123-131. SID. https://sid.ir/paper/90264/en

Vancouver: Copy

KALALIANMOGHADAM H., BALOCHNEJADMOJARAD T., RAOGHANI M., KHAKSARI M., PIRASTEH N., MOJGAN F., AHOOEE M.. THE EFFECT OF BERBERINE CHLORIDE ON HIPPOCAMPUS OXIDATIVE STRESS OF STREPTOZOTOCIN-DIABETIC RATS. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2014;22(SUPPLEMENT):123-131. Available from: https://sid.ir/paper/90264/en

IEEE: Copy

H. KALALIANMOGHADAM, T. BALOCHNEJADMOJARAD, M. RAOGHANI, M. KHAKSARI, N. PIRASTEH, F. MOJGAN, and M. AHOOEE, “THE EFFECT OF BERBERINE CHLORIDE ON HIPPOCAMPUS OXIDATIVE STRESS OF STREPTOZOTOCIN-DIABETIC RATS,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. SUPPLEMENT, pp. 123–131, 2014, [Online]. Available: https://sid.ir/paper/90264/en

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