THE EFFECT OF AGE AND GENDER ON SPINAL MOTONEURONS DEATH FOLLOWING SCIATIC NERVE TRANSACTION IN RAT

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ATABAKI PASDAR F.; PANAHI M.; TAHERI MOGHADAM M.

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2006 | Volume:14 | Issue:1 Page(s): 1-7

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Title

THE EFFECT OF AGE AND GENDER ON SPINAL MOTONEURONS DEATH FOLLOWING SCIATIC NERVE TRANSACTION IN RAT

Author(s)

ATABAKI PASDAR F. | PANAHI M. | TAHERI MOGHADAM M. | Issue Writer Certificate

Keywords

AXOTOMYQ3

RATQ3

APOPTOSISQ3

Abstract

Introduction: For evaluation of age and gender effect on spinal motoneurons death, AXOTOMY or transaction of sciatic nerve were done as an apoptotic model. Material and Methods: The sciatic nerve of Sprague- Dawley RATs were axotomized in the middle of left thigh of the male and female at the age of 3, 5, 7, 10 and 14 days. After 5 days, the animals were sacrificed, the L4-L6 segments of the spinal cord in all groups were removed, fixed, processed and stained with Tionin as a specific staining for Nissle's Body. The number of anterior horn's health -motoneurons in right side as control group and left side as experimental group were counted by light microscopy and compared with each other using analysis of variance. There were 5 male and 5 female animals in each group. Findings: The results showed that the percentage of reduction of motonurons in 3, 5, 7, 10 and 14 days male RATs were 35.38, 33.15, 30.77, 27.64 and 22.58 and in female RATs were 38.95, 36.46, 33.68, 29.50 and 24.97 respectively. On the other hand, the percentage of the reduction in the males compared with the females were significantly lower in all groups (P<0.05). Furthermore, the number of motoneurons in the right side in females was less than males and the difference was significant in 3, 5, 7days old new born (p<0.05).Conclusion: It seems that the gender difference due to androgen activity can affect motoneurons death.

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APA: Copy

ATABAKI PASDAR, F., PANAHI, M., & TAHERI MOGHADAM, M.. (2006). THE EFFECT OF AGE AND GENDER ON SPINAL MOTONEURONS DEATH FOLLOWING SCIATIC NERVE TRANSACTION IN RAT. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 14(1), 1-7. SID. https://sid.ir/paper/90278/en

Vancouver: Copy

ATABAKI PASDAR F., PANAHI M., TAHERI MOGHADAM M.. THE EFFECT OF AGE AND GENDER ON SPINAL MOTONEURONS DEATH FOLLOWING SCIATIC NERVE TRANSACTION IN RAT. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2006;14(1):1-7. Available from: https://sid.ir/paper/90278/en

IEEE: Copy

F. ATABAKI PASDAR, M. PANAHI, and M. TAHERI MOGHADAM, “THE EFFECT OF AGE AND GENDER ON SPINAL MOTONEURONS DEATH FOLLOWING SCIATIC NERVE TRANSACTION IN RAT,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 14, no. 1, pp. 1–7, 2006, [Online]. Available: https://sid.ir/paper/90278/en

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