THE ANALYSIS OF HDAC1 GENE EXPRESSION ALTERATION IN PATIENTS WITH PROSTATE CANCER

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MIRZAEI N.; SHAKARAMI F.; AJAMIAN F.; HAMIDIMADANI A.; SOHANI M.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Ilam University of Medical Sciences Year:2017 | Volume:24 | Issue:6 Page(s): 33-40

Download Full-Text

Persian Verion

View:

1,005

Download:

Cites:

Information Journal Paper

Title

THE ANALYSIS OF HDAC1 GENE EXPRESSION ALTERATION IN PATIENTS WITH PROSTATE CANCER

Author(s)

Keywords

EPIGENETICSQ1

HISTONES MODIFICA-TIONSQ1

GENE EXPRESSIONQ1

HISTONEDEACETYLASE (HDAC)Q1

HISTONE DEACETYLASE INHIBITOR (HDACI)Q1

PROSTATE CANCERQ1

Abstract

Introduction: Chromatin Epigenetic changes have a key role in pathophysiology of PROSTATE CANCER. The most important epigenetic changes are change in DNA methylation, histones modifications, changes in chromatin status and micro RNAs regulatory patterns which are related to tumor creation. Histone deacetylases (HDACs) comprise a large family of enzymes which act as key regulators of nucleosomal histone consistency. HDACs have a great role to start and develop PROSTATE CANCER which is due to changes they create. Epigenetic modifications, in particular DNA hypermethylation and histone acetylation have an essential role in the regulation of genes that protect against PROSTATE CANCER. Since epigenetic changes are reversible, they are interesting targets for cancer therapy. Many epi-drugs such as histone deacetylase inhibitors (HDACi) show anti-cancer properties in either cell culture or in the animal models of PROSTATE CANCER.Materials & methods: In this case-control study, RNA extraction was performed on samples then the expression of HDAC1 in human PROSTATE CANCER using reverse-transcription polymerase chain reaction (RT-PCR). This study was conducted comparing 20 patients diagnosed with PROSTATE CANCER to 20 disease free control subjects.Findings: Our findings suggest that the expression of HDAC1 mRNA is tangible and a significant difference was observed between patients and control subjects.Discussion & conclusions: These results imply that HDAC1 mRNA expression could have potential as a marker and may have prognostic implications for PROSTATE CANCER progression.

Cites

No record.

References

No record.

Cite

APA: Copy

MIRZAEI, N., SHAKARAMI, F., AJAMIAN, F., HAMIDIMADANI, A., & SOHANI, M.. (2017). THE ANALYSIS OF HDAC1 GENE EXPRESSION ALTERATION IN PATIENTS WITH PROSTATE CANCER. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 24(6), 33-40. SID. https://sid.ir/paper/90349/en

Vancouver: Copy

MIRZAEI N., SHAKARAMI F., AJAMIAN F., HAMIDIMADANI A., SOHANI M.. THE ANALYSIS OF HDAC1 GENE EXPRESSION ALTERATION IN PATIENTS WITH PROSTATE CANCER. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2017;24(6):33-40. Available from: https://sid.ir/paper/90349/en

IEEE: Copy

N. MIRZAEI, F. SHAKARAMI, F. AJAMIAN, A. HAMIDIMADANI, and M. SOHANI, “THE ANALYSIS OF HDAC1 GENE EXPRESSION ALTERATION IN PATIENTS WITH PROSTATE CANCER,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 24, no. 6, pp. 33–40, 2017, [Online]. Available: https://sid.ir/paper/90349/en

Related Journal Papers