Proteomics Comparison of Breast Cancer with Adjacent Normal Tissues in Women with Breast Cancer

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Amiri shoar M.; HOSSEINI M.; AWSAT MELLATI A.

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Paper Information

Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2018 | Volume:26 | Issue:1 Page(s): 132-140

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Title

Proteomics Comparison of Breast Cancer with Adjacent Normal Tissues in Women with Breast Cancer

Author(s)

Amiri shoar M. | HOSSEINI M. | AWSAT MELLATI A. | Issue Writer Certificate

Keywords

biomarkerQ1

breast cancerQ1

pathogenesisQ2

proteomQ2

Abstract

Introduction: The molecular mechanisms involved in the development and progression of breast cancer have yet to be determined. In the present study, the proteome of cancerous beast and adjacent normal tissues were compared. Materials & Methods: In a cohort study, the cancer tissues and adjacent normal tissues were obtained from 5 female patients with ductal carcinoma in stage 3. The total protein contents of cancer and adjacent normal tissues were extracted. The protein expression levels were examined by Image Master 2D Platinum software following two-dimensional gel electrophoresis. MALDI-TOF MS/MS mass spectrometry was used for proteins identification. Findings: The constant region of Ig gamma-1 chain and beta subunit of hemoglobin were exclusively detected in the cancer and adjacent normal tissues, respectively. The expression of serum albumin and collagen VI alpha chain in the cancer tissue was significantly lower than the normal tissue (P <0. 05). In contrast, the expression of a single peptide matching to cytoskeletal type I and II keratin significantly increased in the cancer tissue compared to the normal tissues (P <0. 05). Discussion & Conclusion: As the output of our investigation, it seems that proteome of cancerous tissue is extensively different from the adjacent one. Therefore, proteomic approach might be a promising tool for monitoring breast tumorigenesis. However, this needs to be confirmed in future.

Cites

Effect of Twelve Weeks Concurrent Yoga and Pilates Training on Glucose Homeostasis and Insulin Resistance in Breast Cancer Survivors: A Clinical Trial Study

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APA: Copy

Amiri shoar, M., HOSSEINI, M., & AWSAT MELLATI, A.. (2018). Proteomics Comparison of Breast Cancer with Adjacent Normal Tissues in Women with Breast Cancer. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 26(1 ), 132-140. SID. https://sid.ir/paper/90450/en

Vancouver: Copy

Amiri shoar M., HOSSEINI M., AWSAT MELLATI A.. Proteomics Comparison of Breast Cancer with Adjacent Normal Tissues in Women with Breast Cancer. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2018;26(1 ):132-140. Available from: https://sid.ir/paper/90450/en

IEEE: Copy

M. Amiri shoar, M. HOSSEINI, and A. AWSAT MELLATI, “Proteomics Comparison of Breast Cancer with Adjacent Normal Tissues in Women with Breast Cancer,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 26, no. 1 , pp. 132–140, 2018, [Online]. Available: https://sid.ir/paper/90450/en

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