THE ROLE OF RAPID DELAYED RECTIFIER K+CURRENT ON PACEMAKER ACTIVITY OF MOUSE SINOATRIAL AND ATRIOVENTRI-CULAR NODE

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NIKMARAM MOHAMMAD REZA

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Journal: JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES Year:2008 | Volume:16 | Issue:2 Page(s): 21-27

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Title

THE ROLE OF RAPID DELAYED RECTIFIER K+CURRENT ON PACEMAKER ACTIVITY OF MOUSE SINOATRIAL AND ATRIOVENTRI-CULAR NODE

Author(s)

NIKMARAM MOHAMMAD REZA | Issue Writer Certificate

Keywords

SINOATRIAL NODE (SAN)Q3

ATRIOVENTRICULAR NODE (AVN)Q3

LENGTH(CL)Q3

RAPID DELAYED K+CURRENTQ3

E-4031Q3

Abstract

Introduction: In the heart cells, rapid delayed rectifier K+current is one of the important currents for action potential repolarization phase. Rapid delayed rectifier K+current is blocked by low concentration of E-4031. The aim of this research was to compare the effect of E- 4031 blocker on pacemaker activity ofsinoatrial node (SAN) and atrioventricular node (AVN) of mouse heart.Materials & methods: The pacemaker activity of distinct intact SAN and AVN by two separate metal microelectrodes that contact the endothelial surface of nodes, was recorded before and during 1mME- 4031 and cycle length (CL) was measured.Findings: 1 mME-4031 increased CL on SAN preparations by 67.6±12.5 % and on AVN preparations by 28:t3.5 %. These changes were significant in two nodes.Conclusion: It is passable to conclude that 1) the rapid delayed rectifier K+current were present in two nodes 2) the effect of E-4031 on CL of two nodes was different.

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APA: Copy

NIKMARAM, MOHAMMAD REZA. (2008). THE ROLE OF RAPID DELAYED RECTIFIER K+CURRENT ON PACEMAKER ACTIVITY OF MOUSE SINOATRIAL AND ATRIOVENTRI-CULAR NODE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, 16(2), 21-27. SID. https://sid.ir/paper/90502/en

Vancouver: Copy

NIKMARAM MOHAMMAD REZA. THE ROLE OF RAPID DELAYED RECTIFIER K+CURRENT ON PACEMAKER ACTIVITY OF MOUSE SINOATRIAL AND ATRIOVENTRI-CULAR NODE. JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2008;16(2):21-27. Available from: https://sid.ir/paper/90502/en

IEEE: Copy

MOHAMMAD REZA NIKMARAM, “THE ROLE OF RAPID DELAYED RECTIFIER K+CURRENT ON PACEMAKER ACTIVITY OF MOUSE SINOATRIAL AND ATRIOVENTRI-CULAR NODE,” JOURNAL OF ILAM UNIVERSITY OF MEDICAL SCIENCES, vol. 16, no. 2, pp. 21–27, 2008, [Online]. Available: https://sid.ir/paper/90502/en

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