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Information Journal Paper

Title

Fabrication of Liposomal Nanoparticles Containing Hydroalcoholic Extract of Silybum Marianum and Evaluation of Its Toxicity on Human Osteosarcoma Cancer Cell Line (SAOS-2) and Evaluation Effect of Free Hydroalcoholic Extract of Silybum Marianum and Empty Liposomes on Healthy Human Fibroblast Cell (HFF)

Pages

  61-73

Abstract

 Introduction: The aim of this study was to fabricate nanoLiposomes containing Silybum marianum extract and evaluating effect of its toxicity on SAOS-2 cancer cell line and evaluating effect of the toxicity of free extract and empty Liposomes on HFF cell line. Methods: Three liposomal systems containing extract with different molar percentages of soybean phosphatidylcholine(60% and 80%) with cholesterol were prepared by thin film. Then the most suitable formulation was selected according to the loading percentage and release rate. The release pattern of the extract from the selected formulation was evaluated and the size, and surface charge of the particles were investigated. Finally, the toxicity of the selected system containing the extract, and the free extract and the system without the extract on the SAOS-2 cell line, and the toxicity of the free extract and the essential oil-free system on the HFF cell line were measured. Results: amount of extract loading in the selected formulation, particle size, polydispersity index, and zeta potential for the selected formulation were 84. 16 ± 0. 15, 98nm, 0. 286 and-17. 2mV, respectively. The release of the extract is slow at temperatures similar to those of healthy and cancer cells. Also, Liposome extract had more toxicity on SAOS-2 cell line than free extract, and Liposome-free extract and free extract had less toxicity on HFF cell line. Conclusion: Based on the results, the liposomal system containing the extract, with its physicochemical properties and appropriate toxicity on the SAOS-2 cell line, can be a suitable carrier for the delivery of plant compounds to target cells.

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    APA: Copy

    Taebpour, Mohammad, Majdizadeh, Mohammad, & Akhlaghi, Milad. (2021). Fabrication of Liposomal Nanoparticles Containing Hydroalcoholic Extract of Silybum Marianum and Evaluation of Its Toxicity on Human Osteosarcoma Cancer Cell Line (SAOS-2) and Evaluation Effect of Free Hydroalcoholic Extract of Silybum Marianum and Empty Liposomes on Healthy Human Fibroblast Cell (HFF). KNOWLEDGE AND HEALTH, 16(1 ), 61-73. SID. https://sid.ir/paper/952652/en

    Vancouver: Copy

    Taebpour Mohammad, Majdizadeh Mohammad, Akhlaghi Milad. Fabrication of Liposomal Nanoparticles Containing Hydroalcoholic Extract of Silybum Marianum and Evaluation of Its Toxicity on Human Osteosarcoma Cancer Cell Line (SAOS-2) and Evaluation Effect of Free Hydroalcoholic Extract of Silybum Marianum and Empty Liposomes on Healthy Human Fibroblast Cell (HFF). KNOWLEDGE AND HEALTH[Internet]. 2021;16(1 ):61-73. Available from: https://sid.ir/paper/952652/en

    IEEE: Copy

    Mohammad Taebpour, Mohammad Majdizadeh, and Milad Akhlaghi, “Fabrication of Liposomal Nanoparticles Containing Hydroalcoholic Extract of Silybum Marianum and Evaluation of Its Toxicity on Human Osteosarcoma Cancer Cell Line (SAOS-2) and Evaluation Effect of Free Hydroalcoholic Extract of Silybum Marianum and Empty Liposomes on Healthy Human Fibroblast Cell (HFF),” KNOWLEDGE AND HEALTH, vol. 16, no. 1 , pp. 61–73, 2021, [Online]. Available: https://sid.ir/paper/952652/en

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