Effect of Resistance Exercise and Liposomal Vitamin C on Some Factors of Mitochondrial Dynamics and Biogenesis

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Khodabandeh Mostafa; PEERI MAGHSOUD; AZARBAYJANI MOHAMMAD ALI; MATIN HOMAEE HASAN

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Journal: Complementary Medicine Journal Year:2021 | Volume:11 | Issue:1 (38) Page(s): 82-97

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Information Journal Paper

Title

Effect of Resistance Exercise and Liposomal Vitamin C on Some Factors of Mitochondrial Dynamics and Biogenesis

Author(s)

Khodabandeh Mostafa | PEERI MAGHSOUD | AZARBAYJANI MOHAMMAD ALI | MATIN HOMAEE HASAN | Issue Writer Certificate

Keywords

Reactive oxygen specific

PGC-1α

Mitofusin 1

Resistance exercise

Aging

Vitamin C

Abstract

Objective: Aging is associated with some changes in the liver function including increased collagen deposition and decreased mitochondrial function. This study aims to evaluate the effect of Resistance exercise and Vitamin C intake on the expression of Peroxisome Proliferator-Activated Receptor-Γ Coactivator-1α (PGC-1α ) and Mitofusin 1 (MFn1) genes and collagen deposition in older rats. Methods: This is an experimental study conducted on 25 male Wistar rats aged 24 weeks and weighted 280-320 g. They were randomly divided into five groups of young control, older exercise, older Vitamin C, older exercise + Vitamin C, and older control. In the supplementation groups, rats were given liposomal Vitamin C (100 mg/kg per body weight) by gavage daily. One-way ANOVA was used to examine the difference between the groups and Tukey’ s post hoc test was used to determine the location of group differences. For all analyses, the significance level was set at 0. 05. Results: Aging significantly reduced the expression of PGC-1α and MFn1 and increased collagen deposition in the liver tissue of rats (P=0. 001). In the older exercise + Vitamin C group, a significant increase in PGC-1α expression was observed compared to the older control group (P=0. 001), but there was no significant changes in MFn1 expression. A significant decrease in collagen deposition was reported in the older exercise, older Vitamin C, and older exercise + Vitamin C groups compared to the older control group (P=0. 001). Conclusion: Resistance exercise combined with Vitamin C intake reduces collagen deposition in liver tissue and increases PGC-1α expression in older rats.

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APA: Copy

Khodabandeh, Mostafa, PEERI, MAGHSOUD, AZARBAYJANI, MOHAMMAD ALI, & MATIN HOMAEE, HASAN. (2021). Effect of Resistance Exercise and Liposomal Vitamin C on Some Factors of Mitochondrial Dynamics and Biogenesis. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, 11(1 (38) ), 82-97. SID. https://sid.ir/paper/953497/en

Vancouver: Copy

Khodabandeh Mostafa, PEERI MAGHSOUD, AZARBAYJANI MOHAMMAD ALI, MATIN HOMAEE HASAN. Effect of Resistance Exercise and Liposomal Vitamin C on Some Factors of Mitochondrial Dynamics and Biogenesis. COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY[Internet]. 2021;11(1 (38) ):82-97. Available from: https://sid.ir/paper/953497/en

IEEE: Copy

Mostafa Khodabandeh, MAGHSOUD PEERI, MOHAMMAD ALI AZARBAYJANI, and HASAN MATIN HOMAEE, “Effect of Resistance Exercise and Liposomal Vitamin C on Some Factors of Mitochondrial Dynamics and Biogenesis,” COMPLEMENTARY MEDICINE JOURNAL OF FACULTY OF NURSING & MIDWIFERY, vol. 11, no. 1 (38) , pp. 82–97, 2021, [Online]. Available: https://sid.ir/paper/953497/en

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