Effect of Eight Weeks Resistance Training On Gene Expression of TNF-Α and IL10 in the Heart of Type II Diabetic Male Rats

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Soltanian Zahra; VANAKY BEHNAZ; Ramezani Nasrin; Shakeri Nader; SHAMS ZAHRA; Fakhari Rad Fatimah

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2019 | Volume:27 | Issue:6 Page(s): 1656-1667

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Title

Effect of Eight Weeks Resistance Training On Gene Expression of TNF-Α and IL10 in the Heart of Type II Diabetic Male Rats

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Keywords

Type 2 diabetesQ2

HeartQ2

Resistance trainingQ1

Inflammatory factorsQ1

Abstract

Introduction: Type 2 diabetes has many complications, including cardiovascular disease, which is associated with an increase in inflammatory biomarkers. Research has shown that physical activity can reduce Inflammatory factors and improve cardiovascular disease. The purpose of this study was to investigate the effect of resistance exercise on some of the inflammatory and anti-Inflammatory factors in the Heart tissue of type 2 diabetic rats. Methods: In this study, 18 male rats were selected. Rats were diabetic with nicotinamide and streptozotocin (stz) and then randomly divided into 2 groups of control (n=9) and training (n=9). The training group performed a Resistance training program for 8 weeks, 5 days a week. Measurement of TNF-α and IL10 expression in the Heart tissue was determined using the one step SYBR TAKARA single-step kit. To compare the difference between the mean of variables between exercise and control groups, independent t-test and t-test were used also to determine the effect of diabetes induction on variables. To determine the relationship between variables, Pearson correlation coefficient and separation correlation coefficient were used. Data were analyzed by SPSS software version 22. Results: The results showed that the insulin resistance index decreased significantly in the training group compared to the control group. On the other hand, the expression of TNF-α gene decreased and IL10 showed a significant increase (α ≤ 0. 05). Conclusion: The results indicate that Resistance training may be effective in modulating the Inflammatory factors of TNF-α and IL10 in the Heart tissue of type 2 diabetic rats.

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References

An evaluation of low volume high-intensity intermittent training (HIIT) for health risk reduction in overweight and obese men

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APA: Copy

Soltanian, Zahra, VANAKY, BEHNAZ, Ramezani, Nasrin, Shakeri, Nader, SHAMS, ZAHRA, & Fakhari Rad, Fatimah. (2019). Effect of Eight Weeks Resistance Training On Gene Expression of TNF-Α and IL10 in the Heart of Type II Diabetic Male Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 27(6 ), 1656-1667. SID. https://sid.ir/paper/35976/en

Vancouver: Copy

Soltanian Zahra, VANAKY BEHNAZ, Ramezani Nasrin, Shakeri Nader, SHAMS ZAHRA, Fakhari Rad Fatimah. Effect of Eight Weeks Resistance Training On Gene Expression of TNF-Α and IL10 in the Heart of Type II Diabetic Male Rats. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2019;27(6 ):1656-1667. Available from: https://sid.ir/paper/35976/en

IEEE: Copy

Zahra Soltanian, BEHNAZ VANAKY, Nasrin Ramezani, Nader Shakeri, ZAHRA SHAMS, and Fatimah Fakhari Rad, “Effect of Eight Weeks Resistance Training On Gene Expression of TNF-Α and IL10 in the Heart of Type II Diabetic Male Rats,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 27, no. 6 , pp. 1656–1667, 2019, [Online]. Available: https://sid.ir/paper/35976/en

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