Processing the mutation of the S gene (HBs Ag) in patients with chronic hepatitis B and determining their acquired immunodeficiency pattern

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Rezaee Niloufar; SHAHSAVANDI SHAHLA; Samiee Mohammad Reza

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Journal: MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES Year:2020 | Volume:63 | Issue:1 Page(s): 2088-2097

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Title

Processing the mutation of the S gene (HBs Ag) in patients with chronic hepatitis B and determining their acquired immunodeficiency pattern

Author(s)

Rezaee Niloufar | SHAHSAVANDI SHAHLA | Samiee Mohammad Reza | Issue Writer Certificate

Keywords

Chronic hepatitis B infection

mutation

S gene

single nucleotide polymorphism

Abstract

Introduction: The mutated strains resistant to nucleoside / nucleotide analogues of hepatitis B virus (HBV) appear as a result of prolonged use time and the occurrence of single nucleotide polymorphism (SNP) and escape mutations. The aim of this study was to identify selective pressures and mutations in immune escape in the HBsAg (S) gene in patients with chronic HBV. Materials and Methods: In this cross-sectional study conducted in 1397 in Karaj, fifty patients with chronic hepatitis B were classified into two groups under treatment and without treatment. The number of DNA copies of each patient's virus was estimated by real-time PCR, and the sequence of the S gene was determined. The effect of each SNP on I-mutant protein stability and DDG free energy estimation was predicted. Results: The lowest virus load and the highest were estimated to be 1. 10 10 1. 1 and 4. 38 ml 10. 3 ml, respectively. The highest number of mutations leading to the change, including Q101R, T115N, S143L, and Q129P, was determined in a person with a history of drug use. In one untreated patient, mutations in M133T and L175S were observed. mutations in Q129P, S174N, and Y134C were also observed in other individuals with a history of treatment. Of the 8 amino acid changes, LD75S with DDG equal to Kcal / mol 1. 87 had the greatest effect on S protein stability. Conclusion: Based on these data, there is a relationship between SNP virus S gene and mutant origin. Findings from studies of escape mutations can be effective in improving treatment and immunization against Chronic hepatitis B infection.

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APA: Copy

Rezaee, Niloufar, SHAHSAVANDI, SHAHLA, & Samiee, Mohammad Reza. (2020). Processing the mutation of the S gene (HBs Ag) in patients with chronic hepatitis B and determining their acquired immunodeficiency pattern. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, 63(1 ), 2088-2097. SID. https://sid.ir/paper/953504/en

Vancouver: Copy

Rezaee Niloufar, SHAHSAVANDI SHAHLA, Samiee Mohammad Reza. Processing the mutation of the S gene (HBs Ag) in patients with chronic hepatitis B and determining their acquired immunodeficiency pattern. MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2020;63(1 ):2088-2097. Available from: https://sid.ir/paper/953504/en

IEEE: Copy

Niloufar Rezaee, SHAHLA SHAHSAVANDI, and Mohammad Reza Samiee, “Processing the mutation of the S gene (HBs Ag) in patients with chronic hepatitis B and determining their acquired immunodeficiency pattern,” MEDICAL JOURNAL OF MASHHAD UNIVERSITY OF MEDICAL SCIENCES, vol. 63, no. 1 , pp. 2088–2097, 2020, [Online]. Available: https://sid.ir/paper/953504/en

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