ASSESSMENT OF FOENICULUM VULGARE L. METHANOLIC EXTRACT EFFECT ON A MODEL OF PARKINSON’S DISEASE. INDUCED BY ICV INJECTION OF 6-HYDROXYDOPAMIN IN FEMALE RATS, USING BEHAVIORAL TESTS

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NAKISA HASSAN; AYOOBI FATEMEH; EHSANI VAHID; AKRAMIAN MOJTABA; KHAJEHASANI FATEMEH; RAHMANI MOHAMMAD REZA; ALLAHTAVAKOLI MOHAMMAD; SHAMSIZADEH ALI

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Journal: Journal of Birjand University of Medical Sciences Year:2015 | Volume:22 | Issue:2 Page(s): 125-133

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Title

ASSESSMENT OF FOENICULUM VULGARE L. METHANOLIC EXTRACT EFFECT ON A MODEL OF PARKINSON’S DISEASE. INDUCED BY ICV INJECTION OF 6-HYDROXYDOPAMIN IN FEMALE RATS, USING BEHAVIORAL TESTS

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Keywords

PARKINSONQ2

FOENICULUM VULGARE LQ2

6-HYDROXYDOPAMINEQ2

RATQ2

Abstract

Background and Aim: Oxidative stresses are involved in neuronal degeneration of substantia nigra and thereby induction of PARKINSON's disease. It is reported that FOENICULUM VULGARE L. can affect lactating and modulating dopaminergic system activity and antioxidant activity as well. In the present study, the effects of methanolic extract of Foeniculum Vulgare seeds on a PARKINSON’s disease model induced by ICV injection of 6-hydroxydopamin (6-OHDA) in female RATs were investigated.Materials and Methods: In this experimental study, 60 female RATs were randomly divided into 6 equal groups including saline, PARKINSON’s disease and PARKINSON’s groups which were treated by different doses of the extract. PARKINSON’s disease was induced by i.c.v injection of 6-OHDA. Methanolic extract of Foeniculum Vulgare seeds (100 and 200 mg/kg) was gavaged through two ways including repeated gavage (14 days before and 14 days after 6-OHDA injection) and acute gavage (once every day for 14 days after 6- OHDA injection). The induced PARKINSON`s disease. was evaluated using Rotarod and Wire grasping tests on the day 14th after 6-OHDA injection.Results: The findings of the study demonstrated that repeated gavage of Foeniculum Vulgare extract improved motility and muscle tone in PARKINSON’s animals (p<0.05). However, acute gavage of the extract had no significant effect on the performance of PARKINSON’s animals.Conclusion: Results of the current study showed that chronic administration of Feoniculum Vulgare extract may improve PARKINSON’s symptoms in female RATs.

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APA: Copy

NAKISA, HASSAN, AYOOBI, FATEMEH, EHSANI, VAHID, AKRAMIAN, MOJTABA, KHAJEHASANI, FATEMEH, RAHMANI, MOHAMMAD REZA, ALLAHTAVAKOLI, MOHAMMAD, & SHAMSIZADEH, ALI. (2015). ASSESSMENT OF FOENICULUM VULGARE L. METHANOLIC EXTRACT EFFECT ON A MODEL OF PARKINSON’S DISEASE. INDUCED BY ICV INJECTION OF 6-HYDROXYDOPAMIN IN FEMALE RATS, USING BEHAVIORAL TESTS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 22(2), 125-133. SID. https://sid.ir/paper/95357/en

Vancouver: Copy

NAKISA HASSAN, AYOOBI FATEMEH, EHSANI VAHID, AKRAMIAN MOJTABA, KHAJEHASANI FATEMEH, RAHMANI MOHAMMAD REZA, ALLAHTAVAKOLI MOHAMMAD, SHAMSIZADEH ALI. ASSESSMENT OF FOENICULUM VULGARE L. METHANOLIC EXTRACT EFFECT ON A MODEL OF PARKINSON’S DISEASE. INDUCED BY ICV INJECTION OF 6-HYDROXYDOPAMIN IN FEMALE RATS, USING BEHAVIORAL TESTS. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2015;22(2):125-133. Available from: https://sid.ir/paper/95357/en

IEEE: Copy

HASSAN NAKISA, FATEMEH AYOOBI, VAHID EHSANI, MOJTABA AKRAMIAN, FATEMEH KHAJEHASANI, MOHAMMAD REZA RAHMANI, MOHAMMAD ALLAHTAVAKOLI, and ALI SHAMSIZADEH, “ASSESSMENT OF FOENICULUM VULGARE L. METHANOLIC EXTRACT EFFECT ON A MODEL OF PARKINSON’S DISEASE. INDUCED BY ICV INJECTION OF 6-HYDROXYDOPAMIN IN FEMALE RATS, USING BEHAVIORAL TESTS,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 22, no. 2, pp. 125–133, 2015, [Online]. Available: https://sid.ir/paper/95357/en

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