COMPARISON OF BRUCELLOSIS ANTI-ANTIBODY LEVELS FOLLOWING TREATMENT WITH STREPTOMYCIN + DOXYCYCLINE AND RIFAMPIN + DOXYCYCLINE

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EBRAHIMZADEH AZADEH; MADARSHAHIAN F.

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Journal: Journal of Birjand University of Medical Sciences Year:2009 | Volume:15 | Issue:4 (37) Page(s): 49-55

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Title

COMPARISON OF BRUCELLOSIS ANTI-ANTIBODY LEVELS FOLLOWING TREATMENT WITH STREPTOMYCIN + DOXYCYCLINE AND RIFAMPIN + DOXYCYCLINE

Author(s)

EBRAHIMZADEH AZADEH | MADARSHAHIAN F. | Issue Writer Certificate

Keywords

BRUCELLA BRUCELLOSISQ3

SERUMQ3

STREPTOMYCINQ2

RIFAMPINQ3

DOXYCYCLINEQ3

Abstract

Background and Aim: Brucellosis has widespread prevalence and is one of the endemic diseases in our country, Iran. It is estimated that every year almost 500000 cases of Brucellosis-mostly Brucella Melitensisoccur in the world. Any type of brucellosis demands a specific treatment. Thus, this study was conducted to compare reduction of Brucellosis anti-antibody level in the SERUM one year after treatment with two regimens, i.e. STREPTOMYCIN + Doxycyclin and RIFAMPIN + Doxycyclin.Materials and Methods: This experimental study was performed on 100 patients with Brucellosis based on the clinical findings, wright ³ 1/80 and 2ME ³ 1/80. The cases were randomly divided into two groups, one received STREPTOMYCIN + Doxycyclin (50 cases), and the other group was treated by RIFAMPIN + Doxycyclin (50 cases). Then 3, 6 and 12 months after treatment Wright and 2ME tests were performed and their results compared by means of statistics using Chi-Square test.Results: The findings of the study showed that age of the cases ranged between 13 and 78 years and 46% of them were 39-48 years old. Results of the tests revealed no significant differences before treatment ,but immediately after treatment significant differences were observed in the two groups (Wright: P=0.05, 2ME: P=0.005) as in the first group tests tended to be negative more rapidly than in the second group. Wright’s test after 3 months showed significant differences in the two groups (P=0.05) but there were no significant differences at 6 and 12 months following treatment.Conclusion: Regarding the rapidity of negative titers of tests in the first group immediately and 3 months after treatment, it could be inferred that STREPTOMYCIN regimen leads to a more effective treatment with rapid recovery which is also accompanied by reduction in the disease anti-antibody level in the SERUM.

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APA: Copy

EBRAHIMZADEH, AZADEH, & MADARSHAHIAN, F.. (2009). COMPARISON OF BRUCELLOSIS ANTI-ANTIBODY LEVELS FOLLOWING TREATMENT WITH STREPTOMYCIN + DOXYCYCLINE AND RIFAMPIN + DOXYCYCLINE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 15(4 (37)), 49-55. SID. https://sid.ir/paper/95389/en

Vancouver: Copy

EBRAHIMZADEH AZADEH, MADARSHAHIAN F.. COMPARISON OF BRUCELLOSIS ANTI-ANTIBODY LEVELS FOLLOWING TREATMENT WITH STREPTOMYCIN + DOXYCYCLINE AND RIFAMPIN + DOXYCYCLINE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2009;15(4 (37)):49-55. Available from: https://sid.ir/paper/95389/en

IEEE: Copy

AZADEH EBRAHIMZADEH, and F. MADARSHAHIAN, “COMPARISON OF BRUCELLOSIS ANTI-ANTIBODY LEVELS FOLLOWING TREATMENT WITH STREPTOMYCIN + DOXYCYCLINE AND RIFAMPIN + DOXYCYCLINE,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 15, no. 4 (37), pp. 49–55, 2009, [Online]. Available: https://sid.ir/paper/95389/en

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