COMPARISON OF THE EFFICACY OF TWO MONTHS OF TREATMENT WITH CO-TRIMOXASOL + RIFAMPINE VERSUS DOXYCYCLINE + RIFAMPINE IN BRUCELLOSIS

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HASSANJANI ROSHAN M.R.

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Journal: Koomesh Year:2001 | Volume:2 | Issue:2 Page(s): 83-87

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Title

COMPARISON OF THE EFFICACY OF TWO MONTHS OF TREATMENT WITH CO-TRIMOXASOL + RIFAMPINE VERSUS DOXYCYCLINE + RIFAMPINE IN BRUCELLOSIS

Author(s)

HASSANJANI ROSHAN M.R. | Issue Writer Certificate

Keywords

BRUCELLOSISQ3

TREATMENT REGIMENQ4

RELAPSEQ2

THERAPY DURATIONQ4

COTRIMOXASOL + RIFAMPINEQ4

DOXYCYCLINE + RIFAMPINEQ4

Abstract

Introduction: Treatment of BRUCELLOSIS is a medical problem, and regimens of treatment with duration of six weeks have significant RELAPSE. This disease is prevalent in our country. The aim of this study was to compaire the efficacy of two months of treatment with two different regimens. Materials and Methods: From April 1998 to September 2000, this interventional study was performed on patient with BRUCELLOSIS in Yahyanejad hospital in Babol. One of this 2 regimens [Co-Trimoxasol + Rifampine (Regimen I) and Doxycycline + Rifampine (Regimen II)] was randomly prescribed and all cases were followed for 12 months. After treatment, clinical manifestations and RELAPSEs with 2 regimens were examined by Chi-Squaire test. Results: 66 cases with mean age 31.6 ±13.7 years and 63 cases with mean age 36 ±15.4 years were treated by regimen I and II and RELAPSE rate was 10% and 25.3% respectively. In comparison to regimen II, regimen I reduced RELAPSE rate 2.3 folds (P = 0.028). From 23 cases of RELAPSE, 13 cases were female and 10 cases were male and 61% of RELAPSE cases were occurred within six months after treatment. Conclusion: This study showed that Co-trimoxasol + Rifampine in compared with Doxycycline + Rifampine is a preferred regimen. Follow up for one year is necessary following treatment according to find out relapsing cases.

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APA: Copy

HASSANJANI ROSHAN, M.R.. (2001). COMPARISON OF THE EFFICACY OF TWO MONTHS OF TREATMENT WITH CO-TRIMOXASOL + RIFAMPINE VERSUS DOXYCYCLINE + RIFAMPINE IN BRUCELLOSIS. KOOMESH, 2(2), 83-87. SID. https://sid.ir/paper/37550/en

Vancouver: Copy

HASSANJANI ROSHAN M.R.. COMPARISON OF THE EFFICACY OF TWO MONTHS OF TREATMENT WITH CO-TRIMOXASOL + RIFAMPINE VERSUS DOXYCYCLINE + RIFAMPINE IN BRUCELLOSIS. KOOMESH[Internet]. 2001;2(2):83-87. Available from: https://sid.ir/paper/37550/en

IEEE: Copy

M.R. HASSANJANI ROSHAN, “COMPARISON OF THE EFFICACY OF TWO MONTHS OF TREATMENT WITH CO-TRIMOXASOL + RIFAMPINE VERSUS DOXYCYCLINE + RIFAMPINE IN BRUCELLOSIS,” KOOMESH, vol. 2, no. 2, pp. 83–87, 2001, [Online]. Available: https://sid.ir/paper/37550/en

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