The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women

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SHOKRZADEH MOHAMMAD; MOHAMMAD POUR ABBAS; HEIDARI ZEINAB

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Journal: Pars Journal of Medical Sciences Year:2019 | Volume:17 | Issue:1 Page(s): 56-63

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Title

The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women

Author(s)

SHOKRZADEH MOHAMMAD | MOHAMMAD POUR ABBAS | HEIDARI ZEINAB | Issue Writer Certificate

Keywords

Rs1800790

Recurrent abortion

Beta Fibrinogen-455 G/A

Abstract

Introduction: Recurrent abortion is a genetic disorder with different etiologies, as defined by the World Health Organization (WHO), three or more times consecutive pregnancy losses. Genetic anomalies are one of the main etiologies of Recurrent abortion. The purpose of the study was to investigate the association between beta fibrinogen (Rs1800790) gene polymorphism and Recurrent abortion in Iranian women. Materials and Methods: In this case-control study, 101 women with Recurrent abortion (19-41 years) and 50 women with no history of abortion (23-57 years) (controls) were present. Five milliliters of their blood was collected in EDTA tubes in Imam Khomeini hospital, Sari, Iran, during 2017-2018. Genomic DNA was extracted using salting-out method and genotypic study of polymorphism was performed using PCR-RFLP method. Statistical analysis was performed using Medcalc software version 15. Results: Relative frequency of AA, GA, GG genotypes for FGB in patient group were 5. 94%, 29. 7% and 64. 36% and in control group were 2%, 50%, 48% respectively (p= 0. 040). The percentage of G and A alleles was 79% and 21% in patient and 73% and 27% in control groups, respectively (p= 0. 322). Evidence indicated the AA mutant gene does not increase the risk of Recurrent abortion and there is no significant association (p= 0. 472). But GA heterozygote relative to GG reference genotype decrease the risk of Recurrent abortion (OR= 0. 44, 95%CI: 0. 22-1. 90, P= 0. 024). Conclusion: The results showed that Rs1800790 FGB gene polymorphism did not increase the risk of Recurrent abortion.

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APA: Copy

SHOKRZADEH, MOHAMMAD, MOHAMMAD POUR, ABBAS, & HEIDARI, ZEINAB. (2019). The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), 17(1 ), 56-63. SID. https://sid.ir/paper/955932/en

Vancouver: Copy

SHOKRZADEH MOHAMMAD, MOHAMMAD POUR ABBAS, HEIDARI ZEINAB. The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women. PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL)[Internet]. 2019;17(1 ):56-63. Available from: https://sid.ir/paper/955932/en

IEEE: Copy

MOHAMMAD SHOKRZADEH, ABBAS MOHAMMAD POUR, and ZEINAB HEIDARI, “The association of beta fibrinogen-455 G/A (rs1800790) gene polymorphism with recurrent abortion in Iranian women,” PARS JOURNAL OF MEDICAL SCIENCES (JAHROM MEDICAL JOURNAL), vol. 17, no. 1 , pp. 56–63, 2019, [Online]. Available: https://sid.ir/paper/955932/en

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