EFFECTS OF PIMPINELLA ANISUM ON SPREADING DEPRESSION IN RAT NEOCORTICAL TISSUE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

HAGHIR H.; GORJI A.; HAMI J.

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Journal of Birjand University of Medical Sciences Year:2010 | Volume:17 | Issue:3 (44) Page(s): 180-188

Download Full-Text

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Verion

View:

894

Download:

Cites:

Information Journal Paper

Title

EFFECTS OF PIMPINELLA ANISUM ON SPREADING DEPRESSION IN RAT NEOCORTICAL TISSUE

Author(s)

HAGHIR H. | GORJI A. | HAMI J. | Issue Writer Certificate

Keywords

PIMPINELLA ANISUMQ3

BRAIN NEOCORTEXQ3

SPREADING DEPRESSIONQ2

MIGRAINEQ2

Abstract

Background and Aim: It is believed that cortical SPREADING DEPRESSION (CSD) is underlying mechanism of aura and subsequent pain in MIGRAINE. This study was designed to investigate the effect of PIMPINELLA ANISUM on CSD specifications in rat neocortical slices.Materials and Methods: In this experimental study, CSD was induced in rat somatosensory cortical slices using two methods. At the first method, after KCl microinjection, the slices were washed out for 60 minutes with PIMPINELLA ANISUM oil extract in different concentrations (0.01-50 mM/L). At the secon d method, slices were washed at artificial cerebrospinal fluid (ACSF) with low concentration of NaCl. Then, slices were washed with 50 mM/L PIMPINELLA ANISUM oil extract for 60 minutes. In both methods, control cortical slices were washed in low alcohol containing CSF. Using extracellular potentials recording, the frequency, amplitude, duration, and propagation velocity of CSD was measured. All data were statistically analyzed.Results: In KCl induced CSF model, the amplitude (P<0.001) and duration (P<0.02) of CSD was significantly decreased after superfusion of PIMPINELLA ANISUM at higher concentrations with dosedependent route. Nonetheless, adding PIMPINELLA ANISUM insignificantly reduced the propagation velocity of CSD (P=0.3). In CSD induction with low NaCl concentration ACSF model, adding PIMPINELLA ANISUM to washing solution caused reduction of frequency (P=0.03) and amplitude (P=0.048) of CSD. However, the duration of CSD in this model showed no significant difference after using PIMPINELLA ANISUM.Conclusion: Regarding to our results, theoretically, PIMPINELLA ANISUM is able to suppress CSD phenomenon as underlying mechanism of MIGRAINE with aura.

Cites

No record.

References

No record.

Cite

APA: Copy

HAGHIR, H., GORJI, A., & HAMI, J.. (2010). EFFECTS OF PIMPINELLA ANISUM ON SPREADING DEPRESSION IN RAT NEOCORTICAL TISSUE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, 17(3 (44)), 180-188. SID. https://sid.ir/paper/95763/en

Vancouver: Copy

HAGHIR H., GORJI A., HAMI J.. EFFECTS OF PIMPINELLA ANISUM ON SPREADING DEPRESSION IN RAT NEOCORTICAL TISSUE. JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2010;17(3 (44)):180-188. Available from: https://sid.ir/paper/95763/en

IEEE: Copy

H. HAGHIR, A. GORJI, and J. HAMI, “EFFECTS OF PIMPINELLA ANISUM ON SPREADING DEPRESSION IN RAT NEOCORTICAL TISSUE,” JOURNAL OF BIRJAND UNIVERSITY OF MEDICAL SCIENCES, vol. 17, no. 3 (44), pp. 180–188, 2010, [Online]. Available: https://sid.ir/paper/95763/en

Related Journal Papers