The Application of G2013 (α-L-Guluronic acid) as an Anti-Inflammatory Drug Candidate in Treatment of Disease

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BAGHERIAN Zahra; FARAJOLLAHI MOHAMMAD MORAD; MOHSENZADEGAN MONIREH; MIRSHAFIEY ABBAS

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Paper Information

Journal: JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S) Year:2021 | Volume:39 | Issue:616 Page(s): 159-166

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Title

The Application of G2013 (α-L-Guluronic acid) as an Anti-Inflammatory Drug Candidate in Treatment of Disease

Author(s)

BAGHERIAN Zahra | FARAJOLLAHI MOHAMMAD MORAD | MOHSENZADEGAN MONIREH | MIRSHAFIEY ABBAS | Issue Writer Certificate

Keywords

G2013 compound

Guluronic acid

Non-steroidal anti-inflammatory agent

Autoimmune diseases

Cancer

Abstract

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for the treatment of different inflammatory disorders, and shown to have many side effects for patients. G2013 or α-L-Guluronic acid is a new NSAID candidate made from alginate in the pathobiology department of Tehran University of Medical Sciences, Iran, and it has been proven to be safe. G2013 anti-inflammatory, immunosuppressive, and immunomodulatory effects have been reported in previous studies. In many studies, it has been shown that this drug candidate has good potential for treatment of different diseases, and is going through clinical phases. In this review article, first, toxicity and anti-inflammatory effects of G2013 is mentioned, and then its effects on the treatment of oxidative stress, and diseases including rheumatoid arthritis, multiple sclerosis, ankylosing spondylitis, and breast Cancer is also reviewed.

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APA: Copy

BAGHERIAN, Zahra, FARAJOLLAHI, MOHAMMAD MORAD, MOHSENZADEGAN, MONIREH, & MIRSHAFIEY, ABBAS. (2021). The Application of G2013 (α-L-Guluronic acid) as an Anti-Inflammatory Drug Candidate in Treatment of Disease. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), 39(616 ), 159-166. SID. https://sid.ir/paper/958537/en

Vancouver: Copy

BAGHERIAN Zahra, FARAJOLLAHI MOHAMMAD MORAD, MOHSENZADEGAN MONIREH, MIRSHAFIEY ABBAS. The Application of G2013 (α-L-Guluronic acid) as an Anti-Inflammatory Drug Candidate in Treatment of Disease. JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S)[Internet]. 2021;39(616 ):159-166. Available from: https://sid.ir/paper/958537/en

IEEE: Copy

Zahra BAGHERIAN, MOHAMMAD MORAD FARAJOLLAHI, MONIREH MOHSENZADEGAN, and ABBAS MIRSHAFIEY, “The Application of G2013 (α-L-Guluronic acid) as an Anti-Inflammatory Drug Candidate in Treatment of Disease,” JOURNAL OF ISFAHAN MEDICAL SCHOOL (I.U.M.S), vol. 39, no. 616 , pp. 159–166, 2021, [Online]. Available: https://sid.ir/paper/958537/en

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