The Effect of Aerobic Exercise and Vitamin D Supplementation on Hepatic Fas and c-FLIP Levels in Rats Exposed to Oxygenated Water

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Etemadi Hamid Reza; ARSHADI SAJAD; BANAEIFAR ABDOLALI; Azarbayjani MohammadAli

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Journal: Journal of Knowledge & Health in Basic Medical Sciences Year:2021 | Volume:15 | Issue:4 Page(s): 20-27

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Title

The Effect of Aerobic Exercise and Vitamin D Supplementation on Hepatic Fas and c-FLIP Levels in Rats Exposed to Oxygenated Water

Author(s)

Etemadi Hamid Reza | ARSHADI SAJAD | BANAEIFAR ABDOLALI | Azarbayjani MohammadAli | Issue Writer Certificate

Keywords

Apoptosis

Fas

c-FLIP

Liver

Aerobic exercise

Vitamin D

Abstract

Introduction: The aim of the present study was to investigate the effect of regular Aerobic exercise and Vitamin D supplementation on hepatic Apoptosis in rats exposed to oxygenated water (H2O2). Methods: For this purpose, 60 adult male Wistar rats weighed 220± 20 g were randomly divided into ten groups (n=6 in each group) including: control group (C), H2O2 (H), double H2O2 (2H), H2O2 + Vitamin D3 Supplement (HD), double H2O2 + Vitamin D3 Supplement (2HD), H2O2+ Exercise (HE), double H2O2+ Exercise (2HE), H2O2 + Vitamin D3 Supplement + Exercise (HDE), double H2O2 + Vitamin D3 + Exercise (2HDE) and Dimethyl Sulfoxide + Saline (DMSO). Then, the animals were exposed to oxidative stress (intraperitoneal injection of H2O2 3 times a week), Vitamin D3 (intraperitoneal injection daily) and daily treadmill exercise for 8 weeks (duration of training sessions 30 to 60 min, at speeds of 8 to 20 m/min). The rats were sacrificed 24 hours after the last training session and Liver tissue was extracted and Fas and c-FLIP protein concentration was measured by ELISA method. One-way ANOVA was used to compare the between groups differences. Results: The results showed that Fas protein levels were higher in the H, 2H, HD and 2HD groups compared to the control group (P<0. 05) and of c-FLIP protein level was lower in the H and 2H groups compared to the control group (P<0. 05). The 2HE and 2HDE groups also showed less Fas protein level compared to the 2H group (P<0. 05). In addition, the HE group compared to the H group and 2HE and 2HDE groups compared to the 2H group showed higher levels of c-FLIP protein concentration (P<0. 05). Conclusion: Overall, the results of the present study showed that exposure of rats to H2O2 initiates apoptotic cascade in Liver tissue. However, regular treadmill exercise was able to attenuate this effect to a large extent, but Vitamin D3 supplementation did not.

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APA: Copy

Etemadi, Hamid Reza, ARSHADI, SAJAD, BANAEIFAR, ABDOLALI, & Azarbayjani, MohammadAli. (2021). The Effect of Aerobic Exercise and Vitamin D Supplementation on Hepatic Fas and c-FLIP Levels in Rats Exposed to Oxygenated Water. KNOWLEDGE AND HEALTH, 15(4 ), 20-27. SID. https://sid.ir/paper/958612/en

Vancouver: Copy

Etemadi Hamid Reza, ARSHADI SAJAD, BANAEIFAR ABDOLALI, Azarbayjani MohammadAli. The Effect of Aerobic Exercise and Vitamin D Supplementation on Hepatic Fas and c-FLIP Levels in Rats Exposed to Oxygenated Water. KNOWLEDGE AND HEALTH[Internet]. 2021;15(4 ):20-27. Available from: https://sid.ir/paper/958612/en

IEEE: Copy

Hamid Reza Etemadi, SAJAD ARSHADI, ABDOLALI BANAEIFAR, and MohammadAli Azarbayjani, “The Effect of Aerobic Exercise and Vitamin D Supplementation on Hepatic Fas and c-FLIP Levels in Rats Exposed to Oxygenated Water,” KNOWLEDGE AND HEALTH, vol. 15, no. 4 , pp. 20–27, 2021, [Online]. Available: https://sid.ir/paper/958612/en

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