The Effect of Eight Weeks of Endurance Training and Injection of Growth Hormone Lipolytic Fragment (AOD9604) on CK18 and Liver Enzymes of NAFLD-Induced Mice Induced by High-Fat Diet

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DEHBASHI MOHSEN; FATHIE MEHRDAD; ATTARZADEH HOSSEINI SEYYED REZA; MOSAFERI ZIAALDINI MOHAMMAD

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Journal: Journal of Knowledge & Health in Basic Medical Sciences Year:2021 | Volume:15 | Issue:4 Page(s): 12-19

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Title

The Effect of Eight Weeks of Endurance Training and Injection of Growth Hormone Lipolytic Fragment (AOD9604) on CK18 and Liver Enzymes of NAFLD-Induced Mice Induced by High-Fat Diet

Author(s)

DEHBASHI MOHSEN | FATHIE MEHRDAD | ATTARZADEH HOSSEINI SEYYED REZA | MOSAFERI ZIAALDINI MOHAMMAD | Issue Writer Certificate

Keywords

Endurance training

Fragment

Cytokeratin-18

Fatty Liver

Abstract

Introduction: Fatty Liver is on the rise in the world, so the aim of this study was to investigate The effect of eight weeks of Endurance training, injection of growth hormone lipolytic Fragment (AOD9604) on CK18 and liver enzymes of NAFLD on mice induced mice induced by high-fat diet. Methods: In This experimental study, 28 male mice were, divided into four groups(n=7): control (C), Exercise (E), Exercise + Fragment (EA), Fragment without training (A) group. The Medium intensity Endurance training program was performed for eight weeks and 5 sessions per week. The Fragment injection protocol was considered to be 250 picograms per kilogram of body weight per day. Samples were evaluated 48 hours after the last training session. Statistical analysis of the data using the software SPSS version 26, using OneWay ANOVA and post hoc Tukey tests at the significant level (P<0/05) was carried out. Results: CK18 showed a significant decrease compared to the control group only in group E(P=0. 00). HOMA-IR index had a significant decrease in E (P=0. 00) and EA (P=0. 03) groups, but no significant changes in A group. Changes in AST were not significant in any of the groups. ALT levels in all three groups of E (P=0. 00), A(P=0. 00) and EA(P=0. 00) were significantly lower than the control group. Conclusion: Despite not having a negative effect on AOD9604, Endurance training alone showed a better response to this peptide. It seems that Fragmentation along with exercise can be effective in improving Fatty Liver syndrome.

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APA: Copy

DEHBASHI, MOHSEN, FATHIE, MEHRDAD, ATTARZADEH HOSSEINI, SEYYED REZA, & MOSAFERI ZIAALDINI, MOHAMMAD. (2021). The Effect of Eight Weeks of Endurance Training and Injection of Growth Hormone Lipolytic Fragment (AOD9604) on CK18 and Liver Enzymes of NAFLD-Induced Mice Induced by High-Fat Diet. KNOWLEDGE AND HEALTH, 15(4 ), 12-19. SID. https://sid.ir/paper/958990/en

Vancouver: Copy

DEHBASHI MOHSEN, FATHIE MEHRDAD, ATTARZADEH HOSSEINI SEYYED REZA, MOSAFERI ZIAALDINI MOHAMMAD. The Effect of Eight Weeks of Endurance Training and Injection of Growth Hormone Lipolytic Fragment (AOD9604) on CK18 and Liver Enzymes of NAFLD-Induced Mice Induced by High-Fat Diet. KNOWLEDGE AND HEALTH[Internet]. 2021;15(4 ):12-19. Available from: https://sid.ir/paper/958990/en

IEEE: Copy

MOHSEN DEHBASHI, MEHRDAD FATHIE, SEYYED REZA ATTARZADEH HOSSEINI, and MOHAMMAD MOSAFERI ZIAALDINI, “The Effect of Eight Weeks of Endurance Training and Injection of Growth Hormone Lipolytic Fragment (AOD9604) on CK18 and Liver Enzymes of NAFLD-Induced Mice Induced by High-Fat Diet,” KNOWLEDGE AND HEALTH, vol. 15, no. 4 , pp. 12–19, 2021, [Online]. Available: https://sid.ir/paper/958990/en

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